Bony adaptation signs are predictive of anterior head–neck offset remodeling after internal fixation for slipped capital femoral epiphysis: a multicenter study on 217 patients (228 hips) with follow-up until end of growth
DOI:
https://doi.org/10.2340/17453674.2025.45076Keywords:
Adaptive Osseous Changes, Children and Adolescents, Femoral Head-Neck Morphology, Femoral Neck Remodelling, Growth DisturbancesAbstract
Background and purpose: We aimed to evaluate the prognostic value of radiographic factors in predicting femoral head–neck remodeling, cam deformity, and local growth disturbances in slipped capital femoral epiphysis (SCFE) treated with internal fixation (IF) with or without simultaneous closed reduction.
Methods: A retrospective multicenter study on 217 SCFE patients (228 hips) treated with IF in 10 institutions was performed. Hip morphology was assessed using preoperative, postoperative, and end of growth (EG) radiographs and radial MRI scans. Evaluated parameters included: epi-metaphyseal distance, Southwick angle (SA), head–neck offset (HNO), femoral neck varus deformity, and shortening. Depending on the presence of bony adaptation (BA; defined as rounded anterior metaphyseal edge and posterior callus formation, typically indicating slip onset > 4 weeks) at diagnosis hips were divided into Group A (n = 96; without BA) and Group B (n = 132; with BA).
Results: At EG, Group A demonstrated better slip correction, more favorable femoral neck remodeling, and lower risk of residual cam deformity than Group B (15% vs 58%, risk difference –43%, 95% confidence interval –54 to –32). Remodeling occurred in most cases in both groups, but normal values were not uniformly reached. Femoral neck varus deformity and shortening were observed in both groups and attributed to disease-specific growth plate damage rather than transphyseal fixation.
Conclusion: Radiographic signs of BA at diagnosis can predict the risk of cam deformity at EG. Cases without BA have a favorable prognosis, whereas slips with BA have a higher risk of residual deformity. Signs of BA demonstrated a higher predictive value (0.84) than SA > 40° (0.60) or negative HNO < –5 mm (0.57).
Downloads
References
Loder R T. Correlation of radiographic changes with disease severity and demographic variables in children with stable slipped capital femoral epiphysis. J Pediatr Orthop 2008; 28: 284-90. doi: 10.1097/BPO.0b013e3181653bbd. DOI: https://doi.org/10.1097/BPO.0b013e3181653bbd
Green D W, Mogekwu N, Scher D M, Handler S, Chalmers P, Widmann R F. A modification of Klein’s Line to improve sensitivity of the anterior-posterior radiograph in slipped capital femoral epiphysis. J Pediatr Orthop 2009; 29: 449-53. doi: 10.1097/BPO.0b013e3181aa20cd. DOI: https://doi.org/10.1097/BPO.0b013e3181aa20cd
Eijer H, Leunig M, Mahomed M N, Ganz R. Cross-table lateral radiographs for screening of anterior femoral head–neck offset in patients with femoro-acetabular impingement. Hip Int 2001; 11: 37-41. DOI: https://doi.org/10.1177/112070000101100104
Ganz R, Parvizi J, Beck M, Leunig M, Notzli H, Siebenrock K A. Femoroacetabular impingement: a cause for osteoarthritis of the hip. Clin Orthop Relat Res 2003: 112-20. doi: 10.1097/01.blo.0000096804.78689.c2. DOI: https://doi.org/10.1097/01.blo.0000096804.78689.c2
Leunig M, Casillas M M, Hamlet M, Hersche O, Notzli H, Slongo T, et al. Slipped capital femoral epiphysis: early mechanical damage to the acetabular cartilage by a prominent femoral metaphysis. Acta Orthop Scand 2000; 71: 370-5. doi: 10.1080/000164700317393367. DOI: https://doi.org/10.1080/000164700317393367
Ito K, Minka M A 2nd, Leunig M, Werlen S, Ganz R. Femoroacetabular impingement and the cam-effect: a MRI-based quantitative anatomical study of the femoral head-neck offset. J Bone Joint Surg Br 2001; 83: 171-6. doi: 10.1302/0301-620x.83b2.11092. DOI: https://doi.org/10.1302/0301-620X.83B2.0830171
Akiyama M, Nakashima Y, Kitano T, Nakamura T, Takamura K, Kohno Y, et al. Remodelling of femoral head–neck junction in slipped capital femoral epiphysis: a multicentre study. Int Orthop 2013; 37: 2331-6. doi: 10.1007/s00264-013-2047-6. DOI: https://doi.org/10.1007/s00264-013-2047-6
Carter C W, Bixby S, Yen Y M, Nasreddine A Y, Kocher M S. The relationship between cam lesion and physis in skeletally immature patients. J Pediatr Orthop 2014; 34: 579-84. doi: 10.1097/BPO.0000000000000177. DOI: https://doi.org/10.1097/BPO.0000000000000177
Klit J, Gosvig K, Magnussen E, Gelineck J, Kallemose T, Soballe K, et al. Cam deformity and hip degeneration are common after fixation of a slipped capital femoral epiphysis. Acta Orthop 2014; 85: 585-91. doi: 10.3109/17453674.2014.957078. DOI: https://doi.org/10.3109/17453674.2014.957078
Lang P, Panchal H, Delfosse E M, Silva M. The outcome of in-situ fixation of unstable slipped capital femoral epiphysis. J Pediatr Orthop B 2019; 28: 452-457. doi: 10.1097/BPB.0000000000000596. DOI: https://doi.org/10.1097/BPB.0000000000000596
von Elm E, Altman D G, Egger M, Pocock S J, Gotzsche P C, Vandenbroucke J P, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Epidemiology 2007; 18: 800-4. doi: 10.1097/EDE.0b013e3181577654. DOI: https://doi.org/10.1097/EDE.0b013e3181577654
Nötzli H P, Wyss T F, Stoecklin C H, Schmid M R, Treiber K, Hodler J. The contour of the femoral head–neck junction as a predictor for the risk of anterior impingement. J Bone Joint Surg Br 2002; 84: 556-60. doi: 10.1302/0301-620x.84b4.12014. DOI: https://doi.org/10.1302/0301-620X.84B4.0840556
Loder R T, Richards B S, Shapiro P S, Reznick L R, Aronson D D. Acute slipped capital femoral epiphysis: the importance of physeal stability. J Bone Joint Surg Am 1993; 75: 1134-40. doi: 10.2106/00004623-199308000-00002. DOI: https://doi.org/10.2106/00004623-199308000-00002
Kucukkaya M, Karakoyun O, Erol M F. The importance of reaming the posterior femoral cortex before inserting lengthening nails and calculation of the amount of reaming. J Orthop Surg Res 2016; 11: 11. doi: 10.1186/s13018-016-0345-6. DOI: https://doi.org/10.1186/s13018-016-0345-6
Liu Y, Yushan M, Liu Z, Liu J, Ma C, Yusufu A. Application of elliptic registration and three-dimensional reconstruction in the postoperative measurement of Taylor spatial frame parameters. Injury 2020; 51: 2975-80. doi: 10.1016/j.injury.2020.10.077. DOI: https://doi.org/10.1016/j.injury.2020.10.077
Novais E N, Kienle K P, Miller P E, Bowen G, Kim Y J, Bixby S D. Age- and gender-specific variations of the epiphyseal tilt and epiphyseal angle in adolescents without hip pathology. J Child Orthop 2018; 12: 152-9. doi: 10.1302/1863-2548.12.170193. DOI: https://doi.org/10.1302/1863-2548.12.170193
Nectoux E, Decaudain J, Accadbled F, Hamel A, Bonin N, Gicquel P, et al. Evolution of slipped capital femoral epiphysis after in situ screw fixation at a mean 11 years’ follow-up: a 222 case series. Orthop Traumatol Surg Res 2015; 101: 51-4. doi: 10.1016/j.otsr.2014.12.004. DOI: https://doi.org/10.1016/j.otsr.2014.12.004
Anderson M, Herngren B, Tropp H, Risto O. Limited angular remodelling after in-situ fixation for slipped capital femoral epiphysis: a study on radiographs from the Swedish pediatric orthopaedic quality registry for SCFE. BMC Musculoskelet Disord 2024; 25: 11. doi: 10.1186/s12891-023-07117-y. DOI: https://doi.org/10.1186/s12891-023-07117-y
Pollard T C, Villar R N, Norton M R, Fern E D, Williams M R, Simpson D J, et al. Femoroacetabular impingement and classification of the cam deformity: the reference interval in normal hips. Acta Orthop 2010; 81: 134-41. doi: 10.3109/17453671003619011. DOI: https://doi.org/10.3109/17453671003619011
Karaguven D, Demir P, Yuksel S, Omeroglu H. A Delphi consensus study on the treatment of slipped capital femoral epiphysis: considerable consensus in mild and moderate slips and limited consensus in severe slips. J Child Orthop 2023; 17: 299-305. doi: 10.1177/18632521231177272. DOI: https://doi.org/10.1177/18632521231177272
Herngren B, Stenmarker M, Vavruch L, Hagglund G. Slipped capital femoral epiphysis: a population-based study. BMC Musculoskelet Disord 2017; 18: 304. doi: 10.1186/s12891-017-1665-3. DOI: https://doi.org/10.1186/s12891-017-1665-3
Lerch T D, Kim Y J, Kiapour A, Boschung A, Steppacher S D, Tannast M, et al. Hip impingement of severe SCFE patients after in situ pinning causes decreased flexion and forced external rotation in flexion on 3D-CT. J Child Orthop 2023; 17: 411-19. doi: 10.1177/18632521231192462. DOI: https://doi.org/10.1177/18632521231192462
Terjesen T, Wensaas A. Prognostic factors for long-term outcome of chronic slipped capital femoral epiphysis treated with fixation in situ. J Child Orthop 2017; 11: 114-19. doi: 10.1302/1863-2548-11-160285. DOI: https://doi.org/10.1302/1863-2548-11-160285
Veramuthu V, Munajat I, Islam M A, Mohd E F, Sulaiman A R. Prevalence of avascular necrosis following surgical treatments in unstable slipped capital femoral epiphysis (SCFE): a systematic review and meta-analysis. Children (Basel) 2022; 9. doi: 10.3390/children9091374. DOI: https://doi.org/10.3390/children9091374
Loder R T. Effect of femur position on the angular measurement of slipped capital femoral epiphysis. J Pediatr Orthop 2001; 21: 488-94. DOI: https://doi.org/10.1097/01241398-200107000-00014
Jones C E, Cooper A P, Doucette J, Buchan L L, Wilson D R, Mulpuri K, et al. Southwick angle measurements and SCFE slip severity classifications are affected by frog-lateral positioning. Skeletal Radiol 2018; 47: 79-84. doi: 10.1007/s00256-017-2761-z. DOI: https://doi.org/10.1007/s00256-017-2761-z
Additional Files
Published
How to Cite
License
Copyright (c) 2026 Fritz Hefti, Katharina Oder, Renata Pospischill, Bernd Bittersohl, Kathrin Lehnert, Marco Goetze, Danimir Cerkez, Kiril Mladenov, Bjoern Vogt

This work is licensed under a Creative Commons Attribution 4.0 International License.
