A special healing pattern in stable metaphyseal fractures
DOI:
https://doi.org/10.3109/17453674.2014.1003127Abstract
Background and purpose — Metaphyseal fractures heal in a rapid fashion that is different from the bone shaft healing process. Animal studies have focused on diaphyseal fractures. We investigated the metaphyseal fracture-healing process in rabbits. Animals and methods — 60 rabbits (divided into 12 groups) underwent proximal tibial osteotomy, anatomical reduction, and fixation with screws. After surgery, the proximal tibiae were harvested at different time points for histology. Results — No obvious osteonecrosis or bone resorption were found 2 weeks after surgery. From day 5 to week 5, woven bone or new trabeculae formed. From week 2, remodeling into lamellar bone started and reached a peak at week 6. These 3 stages overlapped. Histomorphometry showed that the structure changed as a unimodal curve. Interpretation — The healing process of metaphyseal fractures appears to differ from the commonly studied healing process in diaphyseal fractures. It is rapid, and can be divided into 4 histological stages: cellular activation and differentiation, formation of woven bone, transformation of woven bone into lamellar bone, and further remodeling.Downloads
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Published
2015-03-04
How to Cite
Chen, W. T., Han, D. C., Zhang, P. X., Han, N., Kou, Y. H., Yin, X. F., & Jiang, B. G. (2015). A special healing pattern in stable metaphyseal fractures. Acta Orthopaedica, 86(2), 238–242. https://doi.org/10.3109/17453674.2014.1003127
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Acta Orthopaedica (Scandinavica) content is available freely online as from volume 1, 1930. The journal owner owns the copyright for all material published until volume 80, 2009. As of June 2009, the journal has however been published fully Open Access, meaning the authors retain copyright to their work. As of June 2009, articles have been published under CC-BY-NC or CC-BY licenses, unless otherwise specified.