An increase in myeloid cells after severe injury is associated with normal fracture healing: a retrospective study of 62 patients with a femoral fracture
DOI:
https://doi.org/10.1080/17453674.2018.1501974Abstract
Background and purpose—Nonunion is common in femoral fractures. Previous studies suggested that the systemic immune response after trauma can interfere with fracture healing. Therefore, we investigated whether there is a relation between peripheral blood cell counts and healing of femur fractures. Patients and methods—62 multi-trauma patients with a femoral fracture presenting at the University Medical Centre Utrecht between 2007 and 2013 were retrospectively included. Peripheral blood cell counts from hematological analyzers were recorded from the 1st through the 14th day of the hospital stay. Generalized estimating equations were used to compare outcome groups. Results—12 of the 62 patients developed nonunion of the femoral fracture. The peripheral blood-count curves of total leukocytes, neutrophils, monocytes, lymphocytes, and platelets were all statistically significantly lower in patients with nonunion, coinciding with significantly higher CRP levels during the first 2 weeks after trauma in these patients. Interpretation—Patients who developed femoral nonunion after major trauma demonstrated lower numbers of myeloid cells in the peripheral blood than patients with normal fracture healing. This absent rise of myeloid cells seems to be related to a more severe post-traumatic immune response.Downloads
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Published
2018-09-03
How to Cite
Hesselink, L., Bastian, O. W., Heeres, M., ten Berg, M., Huisman, A., Hoefer, I. E., van Solinge, W. W., Koenderman, L., van Wessem, K. J. P., Leenen, L. P. H., & Hietbrink, F. (2018). An increase in myeloid cells after severe injury is associated with normal fracture healing: a retrospective study of 62 patients with a femoral fracture. Acta Orthopaedica, 89(5), 585–590. https://doi.org/10.1080/17453674.2018.1501974
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Copyright (c) 2018 Lillian Hesselink, Okan W Bastian, Marjolein Heeres, Maarten ten Berg, Albert Huisman, Imo E Hoefer, Wouter W van Solinge, Leo Koenderman, Karlijn J P van Wessem, Luke P H Leenen, Falco Hietbrink
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Acta Orthopaedica (Scandinavica) content is available freely online as from volume 1, 1930. The journal owner owns the copyright for all material published until volume 80, 2009. As of June 2009, the journal has however been published fully Open Access, meaning the authors retain copyright to their work. As of June 2009, articles have been published under CC-BY-NC or CC-BY licenses, unless otherwise specified.