Postoperative mobility is associated with risk of reoperation and increased mortality after hip fracture: a nationwide cohort study of 33,486 patients

Authors

  • Simon Storgaard Jensen Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark https://orcid.org/0000-0002-7565-5656
  • Per Hviid Gundtoft Department of Orthopaedic Surgery, Traumatology, Aarhus University Hospital, Aarhus, Denmark
  • Jan-Erik Gjertsen Department of Orthopaedic Surgery, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Norway https://orcid.org/0000-0002-8490-268X
  • Alma B Pedersen Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark https://orcid.org/0000-0002-3288-9401

DOI:

https://doi.org/10.2340/17453674.2026.45552

Keywords:

Hip, Hip Fracture, Mobility, Mortality, Reoperation

Abstract

Background and purpose: Postoperative mobilization may influence the outcome following hip fracture. We aimed to examine whether regaining pre-fracture basic mobility on discharge is associated with subsequent risk of reoperation and mortality.
Methods: Using nationwide Danish registries, we identified 33,486 patients ≥ 65 years who underwent hip fracture surgery between January 2016 and November 2021. Pre-fracture and discharge mobility were assessed with the Cumulated Ambulation Score (CAS, score 0–6 where 6 is best ambulation). The exposure was regaining pre-fracture CAS at discharge. Adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs) for reoperation and mortality up to 365 days were estimated using Cox regression, adjusting for age, sex, surgery year, length of stay, and comorbidities.
Results: On discharge, 19,329 patients (65%) had not regained pre-fracture CAS. The 30-day reoperation risk was similar among patients who had not regained CAS (2.9%) and those who had (2.5%; aHR 1.10, CI 0.94–1.29). At 365 days, not regaining CAS was associated with a lower reoperation risk (7.1% vs 8.6%; aHR 0.98, CI 0.89–1.07). A CAS loss of 1–2 points was associated with an increased 30-day reoperation risk (aHR 1.20, CI 1.00–1.44). CAS decline was consistently associated with higher mortality at 30 days (aHR 2.07, CI 1.82–2.35) and 365 days (aHR 1.77, CI 1.66–1.89), with progressively higher rates at greater CAS decline.
Conclusion: We found no consistent association between failure to regain pre-fracture mobility on discharge and reoperation, although patients with a 1–2 point CAS loss experienced a modestly higher 30-day reoperation risk. In contrast, failure to regain pre-fracture mobility was strongly associated with increased mortality up to 1 year after hip fracture.

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References

Gjertsen J E, Dybvik E, Furnes O, Fevang J M, Havelin L I, Matre K, et al. Improved outcome after hip fracture surgery in Norway. Acta Orthop 2017; 88(5): 505-11. doi: 10.1080/17453674.2017.1344456. DOI: https://doi.org/10.1080/17453674.2017.1344456

Hjelholt T J, Johnsen S P, Brynningsen P K, Knudsen J S, Prieto-Alhambra D, Pedersen A B. Development and validation of a model for predicting mortality in patients with hip fracture. Age Ageing 2022; 51(1): afab233. doi: 10.1093/ageing/afab233. DOI: https://doi.org/10.1093/ageing/afab233

Goh E L, Png M E, Metcalfe D, Achten J, Appelbe D, Griffin X L, et al. The impact of complications on quality of life and mortality after hip fracture. Bone Joint J 2025; 107-b(10): 1118-24. doi: 10.1302/0301-620x.107b10.Bjj-2024-1448.R1. DOI: https://doi.org/10.1302/0301-620X.107B2.BJJ-2024-0251.R1

Flikweert E R, Wendt K W, Diercks R L, Izaks G J, Landsheer D, Stevens M, et al. Complications after hip fracture surgery: are they preventable? Eur J Trauma Emerg Surg 2018; 44(4): 573-80. doi: 10.1007/s00068-017-0826-2. DOI: https://doi.org/10.1007/s00068-017-0826-2

Fairhall N J, Dyer S M, Mak J C, Diong J, Kwok W S, Sherrington C. Interventions for improving mobility after hip fracture surgery in adults. Cochrane Database Syst Rev 2022; 9(9): Cd001704. doi: 10.1002/14651858.CD001704.pub5. DOI: https://doi.org/10.1002/14651858.CD001704.pub5

National Institute for Health and Care Excellence. The management of hip fracture in adults NICE Full Guideline, 2011 [CG124]. Available from: https://www.nice.org.uk/guidance/cg124 2023 [

The Danish Clinical Quality Program – National Clinical Registries [Regionernes Kliniske Kvalitetsprogram]. Available from: https://www.sundk.dk/kliniske-kvalitetsdatabaser/dansk-tvaerfagligt-register-for-hoftenaere-laarbensbrud/ (Last accessed April, 2025).

Hjelholt T J, Andersen I T, Kristensen M T, Pedersen A B. Early mobilisation after hip fracture surgery reduces the risk of infection: an inverse probability of treatment weighted analysis. Age Ageing 2025; 54(1): afaf007. doi: 10.1093/ageing/afaf007 DOI: https://doi.org/10.1093/ageing/afaf007

Kristensen M T, Öztürk B, Röck N D, Ingeman A, Palm H, Pedersen A B. Regaining pre-fracture basic mobility status after hip fracture and association with post-discharge mortality and readmission: a nationwide register study in Denmark. Age Ageing 2019; 48(2): 278-84. doi: 10.1093/ageing/afy185. DOI: https://doi.org/10.1093/ageing/afy185

Vesterager J D, Kristensen M T, Pedersen A B. Loss of pre-fracture basic mobility status at hospital discharge for hip fracture is associated with 30-day post-discharge risk of infections: a four-year nationwide cohort study of 23,309 Danish patients. Injury 2021; 52(7): 1833-40. doi: 10.1016/j.injury.2021.04.037. DOI: https://doi.org/10.1016/j.injury.2021.04.037

Agarwal N, Feng T, Maclullich A, Duckworth A, Clement N. Early mobilisation after hip fracture surgery is associated with improved patient outcomes: a systematic review and meta-analysis. Musculoskeletal Care 2024; 22(1): e1863. doi: 10.1002/msc.1863. DOI: https://doi.org/10.1002/msc.1863

Elsenosy A M, Yousef A S, Hassan E, Al-Alawi M, Abdelfatah A M, Delewar R A. Early versus delayed weight-bearing following tibial plateau fracture surgery: a systematic review and meta-analysis. Cureus 2025; 17(10): e95185. doi: 10.7759/cureus.95185. DOI: https://doi.org/10.7759/cureus.95185

Wang C, Li C. Early weight-bearing after ankle fracture surgery: a systematic review and meta-analysis of functional outcomes and safety. J Orthop Surg Res 2025; 20(1): 785. doi: 10.1186/s13018-025-06216-x. DOI: https://doi.org/10.1186/s13018-025-06216-x

Bando K, Takegami Y, Ando T, Sugino T, Sato T, Fujita T, et al. Early weight bearing and mobilization decrease perioperative complications in patients after ankle fracture: the retrospective multicenter (TRON group) study. J Orthop Sci 2023; 28(3): 651-5. doi: 10.1016/j.jos.2022.03.002. DOI: https://doi.org/10.1016/j.jos.2022.03.002

Chen Y P, Kuo Y J, Hung S W, Wen T W, Chien P C, Chiang M H, et al. Loss of skeletal muscle mass can be predicted by sarcopenia and reflects poor functional recovery at one year after surgery for geriatric hip fractures. Injury 2021; 52(11): 3446-52. doi: 10.1016/j.injury.2021.08.007. DOI: https://doi.org/10.1016/j.injury.2021.08.007

Hulsbæk S, Larsen R F, Troelsen A. Predictors of not regaining basic mobility after hip fracture surgery. Disabil Rehabil 2015; 37(19): 1739-44. doi: 10.3109/09638288.2014.974836. DOI: https://doi.org/10.3109/09638288.2014.974836

Buecking B, Bohl K, Eschbach D, Bliemel C, Aigner R, Balzer-Geldsetzer M, et al. Factors influencing the progress of mobilization in hip fracture patients during the early postsurgical period? A prospective observational study. Arch Gerontol Geriatr 2015; 60(3): 457-63. doi: 10.1016/j.archger.2015.01.017. DOI: https://doi.org/10.1016/j.archger.2015.01.017

Schmidt M, Schmidt S A J, Adelborg K, Sundbøll J, Laugesen K, Ehrenstein V, et al. The Danish health care system and epidemiological research: from health care contacts to database records. Clin Epidemiol 2019; 11(563-91. doi: 10.2147/clep.S179083. DOI: https://doi.org/10.2147/CLEP.S179083

von Elm E, Altman D G, Egger M, Pocock S J, Gøtzsche P C, Vandenbroucke J P. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. BMJ 2007; 335(7624): 806-8. doi: 10.1136/bmj.39335.541782.AD. DOI: https://doi.org/10.1136/bmj.39335.541782.AD

Kristensen P K, Röck N D, Christensen H C, Pedersen A B. The Danish Multidisciplinary Hip Fracture Registry 13-year results from a population-based cohort of hip fracture patients. Clin Epidemiol 2020; 12: 9-21. doi: 10.2147/clep.S231578. DOI: https://doi.org/10.2147/CLEP.S231578

Hjelholt T J, Edwards N M, Vesterager J D, Kristensen P K, Pedersen A B. The positive predictive value of hip fracture diagnoses and surgical procedure codes in the Danish Multidisciplinary Hip Fracture Registry and the Danish National Patient Registry. Clin Epidemiol 2020; 12: 123-31. doi: 10.2147/clep.S238722. DOI: https://doi.org/10.2147/CLEP.S238722

Schmidt M, Schmidt S A, Sandegaard J L, Ehrenstein V, Pedersen L, Sørensen H T. The Danish National Patient Registry: a review of content, data quality, and research potential. Clin Epidemiol 2015; 7: 449-90. doi: 10.2147/clep.S91125. DOI: https://doi.org/10.2147/CLEP.S91125

Munk-Jørgensen P, Østergaard S D. Register-based studies of mental disorders. Scand J Public Health 2011; 39(7 Suppl): 170-4. doi: 10.1177/1403494810390728. DOI: https://doi.org/10.1177/1403494810390728

Kristensen M T, Andersen L, Bech-Jensen R, Moos M, Hovmand B, Ekdahl C, et al. High intertester reliability of the cumulated ambulation score for the evaluation of basic mobility in patients with hip fracture. Clin Rehabil 2009; 23(12): 1116-23. doi: 10.1177/0269215509342330. DOI: https://doi.org/10.1177/0269215509342330

Jérôme V, Esfandiar C, Morten Tange K, Amandine L, Harold J, Matteo L, et al. Psychometric properties of the Cumulated Ambulation Score French translation. Clin Rehabil 2021; 35(6): 904-10. doi: 10.1177/0269215520984321. DOI: https://doi.org/10.1177/0269215520984321

NOMESCO classification of surgical procedures. Version 1.16 ed. Copenhagen: Nordic Medico-Statistical Committee; 2011. 301 pp.

Storgaard Jensen S, Gundtoft P H, Gjertsen J E, Pedersen A B. Individual and combined effects of somatic and mental disorders on reoperation risk after hip fracture surgery: a nationwide Danish cohort study of 110,625 patients. Eur Geriatr Med 2025. doi: 10.1007/s41999-025-01396-5. DOI: https://doi.org/10.1007/s41999-025-01396-5

Wijnen H H, Schmitz P P, Es-Safraouy H, Roovers L A, Taekema D G, Van Susante J L C. Nonoperative management of hip fractures in very frail elderly patients may lead to a predictable short survival as part of advance care planning. Acta Orthop 2021; 92(6): 728-32. doi: 10.1080/17453674.2021.1959155. DOI: https://doi.org/10.1080/17453674.2021.1959155

Rogmark C, Lynøe N. How to play the final chess match—or at least lose with dignity. Acta Orthopaedica 2021; 92(6): 633-4. doi: 10.1080/17453674.2021.1959159. DOI: https://doi.org/10.1080/17453674.2021.1959159

Furnes O, Gjertsen J-E, Hallan G, Inderhaug E, Gundersen T, Fenstad A M, et al. Annual Report Norwegian Network for Arthroplasty and Hip Fractures 2024. Available from: https://www.helse-bergen.no/48d1eb/contentassets/9f19d57711ee4e60815d6b89e8e8472b/report2024.pdf 2024, (accessed June 16, 2025).

Kristensen M T, Jakobsen T L, Nielsen J W, Jørgensen L M, Nienhuis R J, Jønsson L R. Cumulated Ambulation Score to evaluate mobility is feasible in geriatric patients and in patients with hip fracture. Dan Med J 2012; 59(7): A4464. PMID: 22759844.

Nordström P, Bergman J, Ballin M, Nordström A. Trends in hip fracture incidence, length of hospital stay, and 30-day mortality in Sweden from 1998-2017: a nationwide cohort study. Calcif Tissue Int 2022; 111(1): 21-8. doi: 10.1007/s00223-022-00954-4. DOI: https://doi.org/10.1007/s00223-022-00954-4

Nordström P, Thorngren K G, Hommel A, Ziden L, Anttila S. Effects of geriatric team rehabilitation after hip fracture: meta-analysis of randomized controlled trials. J Am Med Dir Assoc 2018; 19(10): 840-5. doi: 10.1016/j.jamda.2018.05.008. DOI: https://doi.org/10.1016/j.jamda.2018.05.008

Published

2026-03-05

How to Cite

Jensen, S. S., Gundtoft, P. H., Gjertsen, J.-E., & Pedersen, A. B. (2026). Postoperative mobility is associated with risk of reoperation and increased mortality after hip fracture: a nationwide cohort study of 33,486 patients. Acta Orthopaedica, 97, 156–163. https://doi.org/10.2340/17453674.2026.45552

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