The risk of complications in elective orthopedic surgeries in children and young adults with cerebral palsy: a population-based register study
DOI:
https://doi.org/10.2340/17453674.2025.43705Keywords:
Cerebral Palsy, Children, Complications, Orthopedic Surgical Procedures, Paediatric orthopaedicsAbstract
Background and purpose: Musculoskeletal deformities in cerebral palsy (CP) may be surgically treated, but population-based studies of postoperative complications after these surgeries are rare. The aim of our study was to assess the risk of complications following elective orthopedic surgery in children and young adults with CP.
Methods: We performed a register-based cohort study of 1,514 individuals born between 1990 and 2019 who underwent 2,983 orthopedic surgical events between January 1, 1997, and December 31, 2019. Data was obtained from the CP surveillance program CPUP, the Swedish National Patient Register, and the National Cause of Death Register. We used logistic regression to calculate odds ratios (OR) with 95% confidence intervals (CI) for postoperative complications within 90 days, in relation to the Gross Motor Function Classification System (GMFCS) level, anatomic level, and type of surgery (i.e., skeletal vs. soft tissue).
Results: 13% of all surgical events had at least 1 postoperative complication (6% in soft tissue surgeries, 17% in skeletal surgeries), and 51% of these were related to infection. The complication rate was higher in individuals with GMFCS levels IV and V than in the pooled GMFCS levels I–III. The highest ORs were found in GMFCS level V (7.0, CI 3.7–13.5) vs. GMFCS I and spinal surgery (7.9, CI 3.7–13.5) vs. foot/ankle surgery. The OR for skeletal surgery was 1.6 (CI 1.2–2.1) compared with soft tissue surgery.
Conclusion: 13% of all surgical events had at least 1 postoperative complication. The risk of complications after elective orthopedic surgery was higher in children with higher GMFCS levels and in skeletal surgery compared with soft tissue surgery.
Downloads
References
Himmelmann K. Putting prevention into practice for the benefit of children and young people with cerebral palsy. Arch Dis Child 2018; 103: 1100. doi: 10.1136/archdischild-2018-315134. DOI: https://doi.org/10.1136/archdischild-2018-315134
Westbom L, Hägglund G, Nordmark E. Cerebral palsy in a total population of 4–11 year olds in southern Sweden: prevalence and distribution according to different CP classification systems. BMC Pediatr 2007; 7: 41. doi: 10.1186/1471-2431-7-41. DOI: https://doi.org/10.1186/1471-2431-7-41
Hollung S J, Hägglund G, Gaston M S, Seid A K, Lydersen S, Alriksson-Schmidt A I, et al. Point prevalence and motor function of children and adolescents with cerebral palsy in Scandinavia and Scotland: a CP-North study. Dev Med Child Neurol 2021; 63(6): 721-8. doi: 10.1111/dmcn.14764. DOI: https://doi.org/10.1111/dmcn.14764
Rosenbaum P L, Palisano R J, Bartlett D J, Galuppi B E, Russell D J. Development of the Gross Motor Function Classification System for cerebral palsy. Dev Med Child Neurol 2008; 50: 249-53. doi: 10.1111/j.1469-8749.2008.02045.x. DOI: https://doi.org/10.1111/j.1469-8749.2008.02045.x
Aversano M W, Sheikh Taha A M, Mundluru S, Otsuka N Y. What’s new in the orthopaedic treatment of cerebral palsy. J Pediatr Orthop 2017; 37: 210-6. doi: 10.1097/BPO.0000000000000675. DOI: https://doi.org/10.1097/BPO.0000000000000675
Blumetti F C, Wu J C N, Barzi F, Axt M W, Waugh M C, Selber P. Orthopaedic surgery in dystonic cerebral palsy. J Pediatr Orthop 2019; 39: 209-16. doi: 10.1097/BPO.0000000000000919. DOI: https://doi.org/10.1097/BPO.0000000000000919
Telléus A, Kiapekos N, Von Heideken J, Wagner P, Broström E, Hägglund G, et al. Orthopedic surgical procedures in 3,305 children and young adults with cerebral palsy: a register-based cohort study. Acta Orthop 2022; 93: 472-7. doi: 10.2340/17453674.2022.2583. DOI: https://doi.org/10.2340/17453674.2022.2583
DiFazio R, Vessey J A, Miller P, Van Nostrand K, Snyder B. Postoperative complications after hip surgery in patients with cerebral palsy: a retrospective matched cohort study. J Pediatr Orthop 2016; 36: 56-62. doi: 10.1097/BPO.0000000000000404. DOI: https://doi.org/10.1097/BPO.0000000000000404
Butler L R, Dominy C L, White C A, Mengsteab P, Lin E, Allen A K, et al. Risk factors for 90-day readmission and prolonged length of stay after hip surgery in children with cerebral palsy. J Orthop 2023; 38: 14-19. doi: 10.1016/j.jor.2023.03.002. DOI: https://doi.org/10.1016/j.jor.2023.03.002
Yaszay B, Bartley C E, Sponseller P D, Abel M, Cahill P J, Shah S A, et al. Major complications following surgical correction of spine deformity in 257 patients with cerebral palsy. Spine Deform 2020; 8: 1305-1312. doi: 10.1007/s43390-020-00165-7. DOI: https://doi.org/10.1007/s43390-020-00165-7
Shea J, Nunally K D, Miller P E, Difazio R, Matheney T H, Snyder B, et al. Hip reconstruction in nonambulatory children with cerebral palsy: identifying risk factors associated with postoperative complications and prolonged length of stay. J Pediatr Orthop 2020; 40: e972-e977. doi: 10.1097/BPO.0000000000001643. DOI: https://doi.org/10.1097/BPO.0000000000001643
Ruzbarsky J J, Beck NA, Baldwin K D, Sankar W N, Flynn J M, Spiegel D A. Risk factors and complications in hip reconstruction for nonambulatory patients with cerebral palsy. J Child Orthop 2013; 7: 487-500. doi: 10.1007/s11832-013-0536-1. DOI: https://doi.org/10.1007/s11832-013-0536-1
Lindén O, Lauge-Pedersen H, Hägglund G, Wagner P. Development of ankle and knee range of motion after isolated gastrocsoleus lengthening in children with cerebral palsy: a register-based longitudinal cohort study. Acta Orthop 2025; 96: 331-8. doi: 10.2340/17453674.2025.43387. DOI: https://doi.org/10.2340/17453674.2025.43387
Cerebral Pares Uppföljnings Program (CPUP). Available from: https://www.cpup.se.
National Patient Register (NPR). Available from: https://socialstyrelsen.se/en/statistics-and-data/registers/national-patient-register/.
National Cause of Death Register. Available from: https://socialstyrelsen.se/en/statistics-and-data/registers/cause-of-death-register/.
Vandenbroucke J P, von Elm E, Altman D G, Gøtzsche PC, Mulrow C D, Pocock S J, et al. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration. PLoS Med 2007; 4: e297. doi: 10.1371/journal.pmed.0040297. DOI: https://doi.org/10.1371/journal.pmed.0040297
Ludvigsson J F, Andersson E, Ekbom A, Feychting M, Kim J L, Reuterwall C, et al. External review and validation of the Swedish national inpatient register. BMC Public Health 2011; 11: 450. doi: 10.1186/1471-2458-11-450. DOI: https://doi.org/10.1186/1471-2458-11-450
Park H, Castano J, Avila P, Perez D, Berinsky H, Gambarte L, et al. An Information retrieval approach to ICD-10 classification. Stud Health Technol Inform 2019; 264: 1564-5. doi: 10.3233/SHTI190536. DOI: https://doi.org/10.3233/SHTI190536
Alriksson-Schmidt A I, Arner M, Westbom L, Krumlinde-Sundholm L, Nordmark E, Rodby-Bousquet E, et al. A combined surveillance program and quality register improves management of childhood disability. Disabil Rehabil 2017; 39: 830-6. doi: 10.3109/09638288.2016.1161843. DOI: https://doi.org/10.3109/09638288.2016.1161843
National Cancer Institute. Available from: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/complication.
Harvey A, Graham H K, Morris M E, Baker R, Wolfe R. The Functional Mobility Scale: ability to detect change following single event multilevel surgery. Dev Med Child Neurol 2007; 49: 603-7. doi: 10.1111/j.1469-8749.2007.00603.x. DOI: https://doi.org/10.1111/j.1469-8749.2007.00603.x
Vandendriessche E, Proesmans M, Ortibus E, Moens P. Complication rate after scoliosis surgery in children with cerebral palsy. Acta Orthop Belg 2021; 87: 255-61. PMID: 34529378. DOI: https://doi.org/10.52628/87.2.08
Hasler C C. Operative treatment for spinal deformities in cerebral palsy. J Child Orthop 2013; 7: 419-23. doi: 10.1007/s11832-013-0517-4. DOI: https://doi.org/10.1007/s11832-013-0517-4
Nishnianidze T, Bayhan I A, Abousamra O, Sees J, Rogers K J, Dabney K W, et al. Factors predicting postoperative complications following spinal fusions in children with cerebral palsy scoliosis. Eur Spine J 2016; 25: 627-34. doi: 10.1007/s00586-015-4243-0. DOI: https://doi.org/10.1007/s00586-015-4243-0
Verhofste B P, Berry J G, Miller P E, Crofton C N, Garrity B M, Fletcher N D, et al. Risk factors for gastrointestinal complications after spinal fusion in children with cerebral palsy. Spine Deform 2021; 9: 567-578. doi: 10.1007/s43390-020-00233-y. DOI: https://doi.org/10.1007/s43390-020-00233-y
Dodwell E R, Pathy R, Widmann R F, Green D W, Scher D M, Blanco J S, et al. Reliability of the modified Clavien–Dindo–Sink complication classification system in pediatric orthopaedic surgery. JBJS Open Access 2018; 3: e0020. doi: 10.2106/JBJS.OA.18.00020. DOI: https://doi.org/10.2106/JBJS.OA.18.00020
Additional Files
Published
How to Cite
License
Copyright (c) 2025 Anna Telléus, Johan von Heideken, Fredrik Granath, Eva Broström, Gunnar Hägglund, Per Åstrand

This work is licensed under a Creative Commons Attribution 4.0 International License.
