Tissue Reactin to Methyl Methacrylate Monomer: A Comparative Study in the Rabbit's Ear on the Toxicity of Methyl Methacrylate Monomer of Varying Composition

Abstract

The aim of the present investigation was to evaluate if a bone cement monomer with a high concentration of accelerator (N, N-dimethyl-p-toluidine) is more toxic than a methyl methacrylate monomer, free from accelerator. 1) No difference in. the acute local toxicity between CMWR, Simplex-P R and pure methyl methacrylate monomer was seen. 2) By gas chromatography. N, N-dimethyl-p-toIuidine was shown to he water soluble to a small extent. Any bone cement monomer in current use can be fully dissolved in saline to a concentration of about 1 per cent.