Effect of Indomethacin on Collagen Metabolism of Rat Fracture Callus in Vitro
DOI:
https://doi.org/10.3109/17453677809050082Abstract
The collagen metabolism of callus tissue from closed, non-immobilized rat femoral fractures was studied in vitro after in vivo treatment with indomethacin 2 mg/kg/day for 6, 9 and 12 days after fracture. Total hydroxyproline synthesis and incorporation of hydroxyproline into collagen were found to be significantly increased after indomethacin treatment, whereas no significant difference was found regarding collagen resorption. The results Surggest that the recently demonstrated inhibition of fracture healing by indomethacin is not brought about by an inhibition of collagen synthesis.Downloads
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Published
1978-01-01
How to Cite
Rø, J., Langeland, N., & Sander, J. (1978). Effect of Indomethacin on Collagen Metabolism of Rat Fracture Callus in Vitro. Acta Orthopaedica, 49(4), 323–328. https://doi.org/10.3109/17453677809050082
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Acta Orthopaedica (Scandinavica) content is available freely online as from volume 1, 1930. The journal owner owns the copyright for all material published until volume 80, 2009. As of June 2009, the journal has however been published fully Open Access, meaning the authors retain copyright to their work. As of June 2009, articles have been published under CC-BY-NC or CC-BY licenses, unless otherwise specified.
