Myositis Ossificans Progressiva:: Clinical and Metabolical Observations in a Case Treated with a Diphosphonate (EHDP) and Surgical Removal of Ectopic Bone

H. Holmsen; S. Ljunghall; T. Hlerton

doi:10.3109/17453677909024087

Myositis Ossificans Progressiva:: Clinical and Metabolical Observations in a Case Treated with a Diphosphonate (EHDP) and Surgical Removal of Ectopic Bone

Authors

H. Holmsen
S. Ljunghall
T. Hlerton

DOI:

https://doi.org/10.3109/17453677909024087

Abstract

A 20-year-old woman with a severely crippling myositis ossificans progressiva was treated with a diphosphonate (EHDP), 10–20 mg/kg/day. While being treated with this drug, surgical removal of ectopic bone was performed. Although ectopic calcification recurred postoperatively, considerable functional improvement was achieved. At the highest dosage of EHDP, hypercalcaemia gradually appeared, but was reversible upon cessation of drug treatment. It is probably related to a direct effect of EHDP on the bone.

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Published

1979-01-01

How to Cite

Holmsen, H., Ljunghall, S., & Hlerton, T. (1979). Myositis Ossificans Progressiva:: Clinical and Metabolical Observations in a Case Treated with a Diphosphonate (EHDP) and Surgical Removal of Ectopic Bone. Acta Orthopaedica, 50(1), 33–38. https://doi.org/10.3109/17453677909024087

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Issue

Acta Orthopaedica, Volume 50, Issue 1 (1979)

Section

Articles

License

Acta Orthopaedica (Scandinavica) content is available freely online as from volume 1, 1930. The journal owner owns the copyright for all material published until volume 80, 2009. As of June 2009, the journal has however been published fully Open Access, meaning the authors retain copyright to their work. As of June 2009, articles have been published under CC-BY-NC or CC-BY licenses, unless otherwise specified.