The Effect of Indomethacin Upon Experimental Fractures in the Rat
DOI:
https://doi.org/10.3109/17453678208992176Abstract
The effect of Indomethacin upon the process of fracture repair and osteogenesis in bone isografts has been studied in the rat. It was found that the drug had no significant effect upon new bone formation in heterotopic bone grafts. It had no effect upon the osteogenesis in repairing drill holes in 2 month old rats. A significant impairment of osteogenesis was detected, however, in older (6–9 months) animals given continuous treatment with Indomethacin from the week before fracture. This effect was not apparent if treatment was terminated on the day after induction of the lesion. There is histological evidence of increased fibrogenesis and decreased osteogenesis and remodelling in fractures in old rats given high dosages of Indomethacin.Downloads
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Published
1982-01-01
How to Cite
Elves, M. W., Bayley, I., & Roylance, P. J. (1982). The Effect of Indomethacin Upon Experimental Fractures in the Rat. Acta Orthopaedica, 53(1), 35–41. https://doi.org/10.3109/17453678208992176
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Acta Orthopaedica (Scandinavica) content is available freely online as from volume 1, 1930. The journal owner owns the copyright for all material published until volume 80, 2009. As of June 2009, the journal has however been published fully Open Access, meaning the authors retain copyright to their work. As of June 2009, articles have been published under CC-BY-NC or CC-BY licenses, unless otherwise specified.
