Osmium Tetroxide in Antigen-Induced Arthritis: Failure to Inhibit Joint Destruction

Authors

  • Anders S. Henricson
  • Hans T. Telhag
  • Frank A. Wollheim

DOI:

https://doi.org/10.3109/17453678208992173

Abstract

Antigen induced arthritis (AIA) was elicited in 28 adult rabbits using ovalbumin. All animals developed an intensive monarthritis manifested by local heat and swelling. Two, 7 and 21 days later, respectively, 0.3 ml of 1 per cent OsO4 was injected into the arthritic knees of three groups of 9 rabbits. The rabbits were killed 1, 3 and 6 months later. No modifying influence on the severe to complete cartilage destruction was evident. One group of 8 rabbits received only OsO4 and the cartilage of these animals remained intact after 6 months.

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Published

1982-01-01

How to Cite

Henricson, A. S., Telhag, H. T., & Wollheim, F. A. (1982). Osmium Tetroxide in Antigen-Induced Arthritis: Failure to Inhibit Joint Destruction. Acta Orthopaedica, 53(1), 17–21. https://doi.org/10.3109/17453678208992173