Serum Concentrations of Tobramycin® After Intraarticular Administration: An Experimental Study in the Rabbit
DOI:
https://doi.org/10.3109/17453678308996599Abstract
Serum concentration of the aminoglycoside tobramycin was followed for 120 min after intraarticular injection of 20 mg tobramycin in six rabbit knee joints. Highest concentration was observed after 15-30 min, and compared with the values after intramuscular injection the serum half life was equal. No pathological changes were observed by histological examination of the synovial membrane and articular cartilage. It was concluded that no damage of the joint has been demonstrated after intraarticular injection of tobramycin, but the serum concentration must be monitored due to the rapid transport from the joint cavity.Downloads
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Published
1983-03-16
How to Cite
Solgaard, S., Frimodt-møller, N., & Reimann, I. (1983). Serum Concentrations of Tobramycin® After Intraarticular Administration: An Experimental Study in the Rabbit. Acta Orthopaedica, 54(3), 446–448. https://doi.org/10.3109/17453678308996599
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Acta Orthopaedica (Scandinavica) content is available freely online as from volume 1, 1930. The journal owner owns the copyright for all material published until volume 80, 2009. As of June 2009, the journal has however been published fully Open Access, meaning the authors retain copyright to their work. As of June 2009, articles have been published under CC-BY-NC or CC-BY licenses, unless otherwise specified.
