Forelimb malformation in rats caused by cyclophosphamide
DOI:
https://doi.org/10.3109/17453678408992414Abstract
A single dose of cyclophosphamide (20 mg/kg) was administered to female rats on Day 12 of gestation. Fetuses were collected at 24-h intervals from gestation Day 18 to 20. Gross malformations of the forelimb were observed, notably micromelia, oligodactyly, brachydactyly and adactyly. Specimens stained with Alizarin red-s and Alcian blue revealed postaxial skeletal deformities. Chronological histochemical investigations revealed delay in the ossification of the radius and completely unossified ulna; the end results showed the ulna to be more affected than the radius.Downloads
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Published
1984-01-01
How to Cite
Jeyaseelan, N., & Singh, S. (1984). Forelimb malformation in rats caused by cyclophosphamide. Acta Orthopaedica, 55(6), 643–646. https://doi.org/10.3109/17453678408992414
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Acta Orthopaedica (Scandinavica) content is available freely online as from volume 1, 1930. The journal owner owns the copyright for all material published until volume 80, 2009. As of June 2009, the journal has however been published fully Open Access, meaning the authors retain copyright to their work. As of June 2009, articles have been published under CC-BY-NC or CC-BY licenses, unless otherwise specified.
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