Effects on bone of vascular interruption: Turnover and morphology in isotope-prelabelled rats

Authors

  • Leroy Klein
  • Beth Dollinger
  • Victor M. Goldberg
  • Jocelyn M. Zika
  • Arnold E. Powell
  • Kingsbury G. Heiple

DOI:

https://doi.org/10.3109/17453678508992979

Abstract

The effects of bone devascularization were evaluated histologically and metabolically in rats prelabelled with 45Ca, 3H-tetracycline and 3H-proline by quantifying cortical bone resorption and formation. The interruption of blood supply to bone without invading its integrity resulted in a marked increase in bone turnover (resorption and formation) during the first and second months. The stimulated increase in bone resorption and formation did not affect the resultant mass of collagen and calcium. Thus, the increase in bone resorption was compensated by an equivalent increase in bone formation.

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Published

1985-01-01

How to Cite

Klein, L., Dollinger, B., Goldberg, V. M., Zika, J. M., Powell, A. E., & Heiple, K. G. (1985). Effects on bone of vascular interruption: Turnover and morphology in isotope-prelabelled rats. Acta Orthopaedica, 56(1), 47–51. https://doi.org/10.3109/17453678508992979