Effects of short-term treatment with corticosteroids and indomethacin on bone healing

Authors

  • Hans E Høgevold
  • Bjarne Grøgaard
  • Olav Reikerås

DOI:

https://doi.org/10.1080/17453679209169718

Abstract

We studied the effects of short-term therapy with methylprednisolone and indomethacin on healing of intramedullary pinned osteotomies of the femur in rats. When the osteotomy was complete and healing occurred under unstable conditions with callus formation, indomethacin inhibited healing when estimated by mechanical tests of bending moment, energy expenditure before refracture, and bending rigidity 6 weeks after surgery. No inhibitory effects were seen following corticosteroid treatment. When the osteotomy was incomplete and healing occurred under stable conditions, similar tendencies were observed. Thus, short-term medication with indomethacin inhibits fracture healing. This was not the case with short-term methylprednisolone.

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Published

1992-01-01

How to Cite

Høgevold, H. E., Grøgaard, B., & Reikerås, O. (1992). Effects of short-term treatment with corticosteroids and indomethacin on bone healing. Acta Orthopaedica, 63(6), 607–611. https://doi.org/10.1080/17453679209169718

Issue

Acta Orthopaedica, Volume 63, Issue 6 (1992)

Section

Articles

License

Acta Orthopaedica (Scandinavica) content is available freely online as from volume 1, 1930. The journal owner owns the copyright for all material published until volume 80, 2009. As of June 2009, the journal has however been published fully Open Access, meaning the authors retain copyright to their work. As of June 2009, articles have been published under CC-BY-NC or CC-BY licenses, unless otherwise specified.
 
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