No effects of local somatomedin C on bone repair
DOI:
https://doi.org/10.3109/17453679209154765Abstract
We studied the effect of continuous local application of human recombinant somatomedin C (110 µg/100 g/day) on bone repair in a rat femoral osteotomy model. The mechanical strength and various metabolic variables were evaluated four weeks postoperatively. We did not find any effect in the treatment group as compared to controls on torsional strength, deformation, or stiffness. Radiographic healing was similar in both groups. Nor was there any difference in callus weight, callus vascularization, or mineralization. Our results suggest that local administration of this dose of somatomedin C does not promote the early phase of diaphyseal repair in long bones.Downloads
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Published
1992-01-01
How to Cite
Kirkeby, O. J., & Ekeland, A. (1992). No effects of local somatomedin C on bone repair. Acta Orthopaedica, 63(4), 447–450. https://doi.org/10.3109/17453679209154765
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Acta Orthopaedica (Scandinavica) content is available freely online as from volume 1, 1930. The journal owner owns the copyright for all material published until volume 80, 2009. As of June 2009, the journal has however been published fully Open Access, meaning the authors retain copyright to their work. As of June 2009, articles have been published under CC-BY-NC or CC-BY licenses, unless otherwise specified.
