Transforming growth factor-β enhances fracture healing in rabbit tibiae
DOI:
https://doi.org/10.3109/17453679308993691Abstract
The ability of exogenous Transforming Growth Factor-β (TGF-β) to stimulate bone formation in fracture healing was investigated. TGF-β was continuously applied in doses of 1 and 10 μg/day for 6 weeks to 2 groups of adult rabbits with unilateral plated midtibial osteotomies. A group receiving solvent without TGF-β served as control. Fracture healing was evaluated by mechanical tests, bone morphometry and bone densitometry. Increased maximal bending strength and callus formation were demonstrated in the groups receiving TGF-β. TGF-β had no effect on bending-stiffness, bone mineral content, cortical thickness or haversian canal diameter. We conclude that local application of exogenous TGF-β may enhance fracture healing in rabbits.Downloads
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Published
1993-01-01
How to Cite
Lind, M., Schumacker, B., Søballe, K., Keller, J., Melsen, F., & Bünger, C. (1993). Transforming growth factor-β enhances fracture healing in rabbit tibiae. Acta Orthopaedica, 64(5), 553–556. https://doi.org/10.3109/17453679308993691
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Acta Orthopaedica (Scandinavica) content is available freely online as from volume 1, 1930. The journal owner owns the copyright for all material published until volume 80, 2009. As of June 2009, the journal has however been published fully Open Access, meaning the authors retain copyright to their work. As of June 2009, articles have been published under CC-BY-NC or CC-BY licenses, unless otherwise specified.
