Serum collagenase-like peptidase activity correlated with bone mineral density: A study of 102 elderly women

Authors

  • Hideki Ueda
  • Atsushi Harada
  • Ryouichi Katoh
  • Masako Hagihara
  • Takayuki Miura
  • Hisashi Iwata
  • Toshiharu Nagatsu

DOI:

https://doi.org/10.3109/17453679308993628

Abstract

To clarify the relationship between collagenase-like peptidase (CL-peptidase) and bone metabolism, serum CL-peptidase activity and bone mineral density (BMD) in the lumbar spine, measured by dual energy X-ray absorptiometry (DEXA), were determined in 102 women with a mean age of 70 (41–94) years. The serum activity of CL-peptidase increased slightly with age up to the 8th decade, and then decreased. Next, we classified the subjects into the following 2 groups by age: a postmenopausal group 50–69 years, and an elderly group over 70 years. In the younger group serum CL-peptidase activity did not correlate with BMD, while in the elderly it did. Our result suggests that serum CL-peptidase activity may reflect bone resorption in elderly women.

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Published

1993-01-01

How to Cite

Ueda, H., Harada, A., Katoh, R., Hagihara, M., Miura, T., Iwata, H., & Nagatsu, T. (1993). Serum collagenase-like peptidase activity correlated with bone mineral density: A study of 102 elderly women. Acta Orthopaedica, 64(3), 294–296. https://doi.org/10.3109/17453679308993628

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