Clodronate prevents immobilization osteopenia in rats
DOI:
https://doi.org/10.3109/17453679408994622Abstract
We investigated the effect of clodronate on immobilization osteopenia (IO) induced by sciatic neurectomy in rats. 100 Wistar female rats were divided into 5 groups of 20 animals each: 1) sham-operated, control group, 2) IO + saline control group, 3) IO + clodronate 3 mg/kg/day, 4) IO + clodronate 10 mg/kg/day, and 5) IO + clodronate 30 mg/kg/day. Clodronate was administered subcuta-neously beginning on the day after nerve sectioning. After 7 weeks, the animals were killed and both tibiae were removed. Bone mineral density, ash weight and calcium, phosphorus and magnesium contents of the ash of the tibiae were analyzed.Downloads
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Published
1994-01-01
How to Cite
Tarvainen, R., Arnala, L., Olkkonen, H., Lappalainen, R., Nevalainen, T., & Alhava, E. (1994). Clodronate prevents immobilization osteopenia in rats. Acta Orthopaedica, 65(6), 643–646. https://doi.org/10.3109/17453679408994622
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Acta Orthopaedica (Scandinavica) content is available freely online as from volume 1, 1930. The journal owner owns the copyright for all material published until volume 80, 2009. As of June 2009, the journal has however been published fully Open Access, meaning the authors retain copyright to their work. As of June 2009, articles have been published under CC-BY-NC or CC-BY licenses, unless otherwise specified.
