Regulation of hyaluronan synthesis and the interaction of hyaluronan with cells

Authors

  • Paraskevi Heldin
  • Tomas Asplund
  • Priit Teder
  • Masanobu Suzuki
  • Dionisios Vrochides
  • Vasilios Papanikolaou
  • Håkan Pertoft

DOI:

https://doi.org/10.3109/17453679509157682

Abstract

Hyaluronan is a high molecular weight polysaccharide ubiquitously found in the extracellular matrix. It acts as a lubricant in joints and tissues and provides stability and elasticity to the extracellular matrix. In addition, hyaluronan is directly or indirectly implicated in cell growth, angiogenesis, differentiation and malignant tumor invasion (for a review see Laurent and Fraser 1992, Sherman et al. 1994). This review focuses on the regulation of the biosynthesis of hyaluronan and the formation and structure of the pericellular coat around hyaluronan producing cells.

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Published

1995-01-01

How to Cite

Heldin, P., Asplund, T., Teder, P., Suzuki, M., Vrochides, D., Papanikolaou, V., & Pertoft, H. (1995). Regulation of hyaluronan synthesis and the interaction of hyaluronan with cells. Acta Orthopaedica, 66(sup266), 160–162. https://doi.org/10.3109/17453679509157682