The TNF-MMP-matrix network and serum markers for cartilage synthesis and degradation
DOI:
https://doi.org/10.3109/17453679509157679Abstract
TNF has been shown to affect articular matrix integrity by different mechanisms; directly by inhibiting proteoglycan aggrecan synthesis and indirectly by up-regulating matrix metalloproteinases (MMPs) mediating collagen and proteoglycan aggrecan degradation. The net effect of TNF on articular matrix remodeling / degradation in rheumatoid arthritis and the effect of synovial TNF inhibition may be reflected in patients by changes in serum profiles of immunochemical markers which represent important research tools in the clinical development of novel anti-rheumatic agents.Downloads
Download data is not yet available.
Downloads
Published
1995-01-01
How to Cite
Fenner, H., Taylor, D., Follkers, G., & Zueger, S. (1995). The TNF-MMP-matrix network and serum markers for cartilage synthesis and degradation. Acta Orthopaedica, 66(sup266), 156–157. https://doi.org/10.3109/17453679509157679
Issue
Section
Articles
License
Acta Orthopaedica (Scandinavica) content is available freely online as from volume 1, 1930. The journal owner owns the copyright for all material published until volume 80, 2009. As of June 2009, the journal has however been published fully Open Access, meaning the authors retain copyright to their work. As of June 2009, articles have been published under CC-BY-NC or CC-BY licenses, unless otherwise specified.
