Oxygen-free radicals impair fracture healing in rats
DOI:
https://doi.org/10.3109/17453679508995590Abstract
We studied the effect of oxygen-free radicals on fracture healing. 30 male rats were divided into 2 groups: 15 rats were given saline 5 mL/kg i.p. (control group) and 15 were given zymosan 100 mg/kg i.p. to induce oxygen-free radicals through stimulation of NADPH oxidase in polymorphonuclear leucocytes. 1 hour later, the right forelimbs of the rats were broken by light manual compression. These treatments were given once a day until the fifth post-fracture day. All rats were killed on day 22, and histological sections of the radius and ulna were examined without knowledge of the treatment given. The administration of zymosan impaired the fracture healing and therefore oxygen-free radicals appear to play an important role in fracture healing.Downloads
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Published
1995-01-01
How to Cite
Göktürk, E., Turgut, A., Baygu, C., Gunal, I., Seber, S., & Gulbas, Z. (1995). Oxygen-free radicals impair fracture healing in rats. Acta Orthopaedica, 66(5), 473–475. https://doi.org/10.3109/17453679508995590
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Acta Orthopaedica (Scandinavica) content is available freely online as from volume 1, 1930. The journal owner owns the copyright for all material published until volume 80, 2009. As of June 2009, the journal has however been published fully Open Access, meaning the authors retain copyright to their work. As of June 2009, articles have been published under CC-BY-NC or CC-BY licenses, unless otherwise specified.
