In vitro elution of ofloxacin from a bioabsorbable polymer
DOI:
https://doi.org/10.3109/17453679508995563Abstract
A drawback with antibiotic-loaded polymethylmethacrylate (PMMA) beads is the second surgical procedure that may be required to remove the beads. We explored alternatives for the local delivery of antimicrobials and studied the release characteristics of ofloxacin (10 mg) when incorporated into either 30 or 50 mg beads of two different molar ratios of a bioabsorbable lactide: glycolide polymer. An elution method was employed over a 60-day period at 37°C. After 60 days, about half of the ofloxacin had been released from the composites containing 50 mg and 30 mg of the 85:15 polymer, whereas nearly all of the ofloxacin had been released from both sizes of the 50:50 polymer composites.Downloads
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Published
1995-01-01
How to Cite
Nie, L., Nicolau, D. P., Nightingale, C. H., Browner, B. D., & Quintiliani, R. (1995). In vitro elution of ofloxacin from a bioabsorbable polymer. Acta Orthopaedica, 66(4), 365–368. https://doi.org/10.3109/17453679508995563
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Acta Orthopaedica (Scandinavica) content is available freely online as from volume 1, 1930. The journal owner owns the copyright for all material published until volume 80, 2009. As of June 2009, the journal has however been published fully Open Access, meaning the authors retain copyright to their work. As of June 2009, articles have been published under CC-BY-NC or CC-BY licenses, unless otherwise specified.
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