Pigmented villonodular synovitis: Monoclonality and metastasis—a case for neoplastic origin?

Authors

  • Peter F M Choong
  • Helena Willen
  • Mef Nilbert
  • Fredrik Mertens
  • Nils Mandahl
  • Birgitta Carlen
  • Anders Rydholm

DOI:

https://doi.org/10.3109/17453679508994643

Abstract

We report a 48-year follow-up of a case of recurrent pigmented villonodular synovitis of the knee. Subcutaneous metastasis to the contralateral thigh was an unusual finding. Histology demonstrated fibroblastic and histiocytic proliferation, as well as increased mitotic activity in recurrent lesions. Cytogenetic analyses demonstrated monoclonality and chromosomal abnormalities. Our findings support a neoplastic origin of this lesion.

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Published

1995-01-01

How to Cite

Choong, P. F. M., Willen, H., Nilbert, M., Mertens, F., Mandahl, N., Carlen, B., & Rydholm, A. (1995). Pigmented villonodular synovitis: Monoclonality and metastasis—a case for neoplastic origin?. Acta Orthopaedica, 66(1), 64–68. https://doi.org/10.3109/17453679508994643

Issue

Acta Orthopaedica, Volume 66, Issue 1 (1995)

Section

Articles

License

Acta Orthopaedica (Scandinavica) content is available freely online as from volume 1, 1930. The journal owner owns the copyright for all material published until volume 80, 2009. As of June 2009, the journal has however been published fully Open Access, meaning the authors retain copyright to their work. As of June 2009, articles have been published under CC-BY-NC or CC-BY licenses, unless otherwise specified.
 
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