Severe hindlimb ischemia causes periosteal proliferation in the rat tibia

Authors

  • Sigmund Skjeldal
  • Aud Svindland
  • Kjetil Hvaal
  • Trygve Kase
  • Olav Reikerås
  • Lars Nordsletten

DOI:

https://doi.org/10.3109/17453679708999033

Abstract

In this rat study, we found tibial periosteal hyperplasia and hypertrophy, and appositional new bone formation 3 days after transient hindlimb ischemia. This response was positively correlated to the extent of muscle necrosis, which was increased either by raising the environmental temperature during ischemia or by prolonging the period of ischemia. By changing the temperature from 21 °C to 34 °C, the area periost in percent of the total tibial area was increased from 5 to 17, and by changing the duration of ischemia from 3 to 5 hours, it increased from 8 to 18.

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Published

1997-01-01

How to Cite

Skjeldal, S., Svindland, A., Hvaal, K., Kase, T., Reikerås, O., & Nordsletten, L. (1997). Severe hindlimb ischemia causes periosteal proliferation in the rat tibia. Acta Orthopaedica, 68(6), 593–597. https://doi.org/10.3109/17453679708999033