Insulin-like growth factor I increases bone formation in old or corticosteroid treated rats
DOI:
https://doi.org/10.3109/17453679708999032Abstract
We studied bone induction in subcutaneous implants of demineralized bone matrix with or without insulin-like growth factor I (IGF-I) in aged or corticos-teroid-treated rats. Each rat carried one pair of implants, one control and one experiment implant, containing IGF-I dissolved in a hyaluronan solution for slow release. The rats were killed after 3 weeks and the results were evaluated by measuring the calcium content of implants. Young (6–7 weeks) and old (19–27 months) rats were used. A group of young rats was treated for 1 week with subcutaneous injections of 140 ng/kg dexamethasone daily. Old rats produced only approximately 1 % as much bone as young rats. Local delivery of IGF-I did not increase bone formation in young rats. In old rats, bone formation was increased by IGF-I, 3000 ng/implant. Corticosteroids reduced bone formation in young rats. This effect was partially reversed by local administration of IGF-I.Downloads
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Published
1997-01-01
How to Cite
Prisell, P. T., Aspenberg, P., Wikstrom, B., Wredmark, T., & Norstedt, G. (1997). Insulin-like growth factor I increases bone formation in old or corticosteroid treated rats. Acta Orthopaedica, 68(6), 586–592. https://doi.org/10.3109/17453679708999032
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Acta Orthopaedica (Scandinavica) content is available freely online as from volume 1, 1930. The journal owner owns the copyright for all material published until volume 80, 2009. As of June 2009, the journal has however been published fully Open Access, meaning the authors retain copyright to their work. As of June 2009, articles have been published under CC-BY-NC or CC-BY licenses, unless otherwise specified.
