Expression of BMP-4 mRNA during distraction osteogenesis in rabbits

Authors

  • Gang Li
  • Sigurd Berven
  • Hamish Simpson
  • James T Triffitt

DOI:

https://doi.org/10.3109/17453679808999060

Abstract

We characterized the presence and localization of bone morphogenetic protein 4 (BMP-4) mRNA in the regenerating tissues produced by distraction osteogenesis following tibial osteotomy in the rabbit. The findings are consistent with previous reports on the localization of BMP-4 mRNA expression during fracture repair. The BMP-4 gene is expressed by less differentiated osteoprogenitor cells (fibroblastic mesbenchymal cells and preosteoblasts), and not by fully differentiated osteoblasts. BMP-4 gene expression is localized in callus-forming tissue (muscle, periosteum) during callus formation. Our observations suggest that the BMP-4 gene product is one of the local contributing factors in regulating bone and cartilage formation in distraction osteogenesis.

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Published

1998-01-01

How to Cite

Li, G., Berven, S., Simpson, H., & Triffitt, J. T. (1998). Expression of BMP-4 mRNA during distraction osteogenesis in rabbits. Acta Orthopaedica, 69(4), 420–425. https://doi.org/10.3109/17453679808999060

Issue

Acta Orthopaedica, Volume 69, Issue 4 (1998)

Section

Articles

License

Acta Orthopaedica (Scandinavica) content is available freely online as from volume 1, 1930. The journal owner owns the copyright for all material published until volume 80, 2009. As of June 2009, the journal has however been published fully Open Access, meaning the authors retain copyright to their work. As of June 2009, articles have been published under CC-BY-NC or CC-BY licenses, unless otherwise specified.
 
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