Role of multinuclear cells in granulation tissue in osteomyelitis: Immunohistochemistry in 66 patients
DOI:
https://doi.org/10.1080/000164700317393448Abstract
We investigated the origin of multinuclear cells (MNCs) in the granulation tissue in osteomyelitis by immunohistochemical techniques in 66 patients. 12 samples were analyzed for the presence of CD68, cathepsin K, CD11b and tartrate-resistant acid phosphatase (TRAP) activity. Many MNCs were present in the granulation tissue adjacent to a sequestrum. MNCs in contact with the sequestrum were also noted, however, no osteoblasts were found. Immunohistochemically, CD68, cathepsin K and TRAP were strongly expressed in most of the MNCs, while CD11b positive cells were not found. MNCs remote from and in contact with the sequestrum showed the same immunohistochemical features which are characteristic of osteoclasts. Further, MNCs in contact with the sequestrum had originally developed in the granulation tissue and directly infiltrated towards the sequestrum without cellto-cell interaction with osteoblasts.Downloads
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Published
2000-01-01
How to Cite
Kataoka, M., Torisu, T., Tsumura, H., Hirayama, T., & Fujikawa, Y. (2000). Role of multinuclear cells in granulation tissue in osteomyelitis: Immunohistochemistry in 66 patients. Acta Orthopaedica, 71(4), 414–418. https://doi.org/10.1080/000164700317393448
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Acta Orthopaedica (Scandinavica) content is available freely online as from volume 1, 1930. The journal owner owns the copyright for all material published until volume 80, 2009. As of June 2009, the journal has however been published fully Open Access, meaning the authors retain copyright to their work. As of June 2009, articles have been published under CC-BY-NC or CC-BY licenses, unless otherwise specified.
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