Changes in the production and the effect of nitric oxide with aging in articular cartilage: An experimental study in rabbits
DOI:
https://doi.org/10.1080/000164702317281332Abstract
We studied the production and the effect of nitric oxide (NO) in articular cartilage from rabbits of various ages. 40 New Zealand white rabbits in 4 age groups (1 month, 6 months, 1 year, and 3 years of age with 10 rabbits in each group) were used. Basal and induced levels of NO were lower in cultured chondrocytes from older rabbits. Exogenous NO administration suppressed the proliferative activity of chondrocytes to a greater degree in younger rabbits. Immunohistochemistry showed that older rabbits had fewer eNOS positive chondrocytes. Our findings imply that the age-related change in NO in articular cartilage does not have a relevance to increased NO production in osteoarthrosis.Downloads
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Published
2002-01-01
How to Cite
Im, G.-I., & Shin, S.-R. (2002). Changes in the production and the effect of nitric oxide with aging in articular cartilage: An experimental study in rabbits. Acta Orthopaedica, 73(1), 6–10. https://doi.org/10.1080/000164702317281332
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Acta Orthopaedica (Scandinavica) content is available freely online as from volume 1, 1930. The journal owner owns the copyright for all material published until volume 80, 2009. As of June 2009, the journal has however been published fully Open Access, meaning the authors retain copyright to their work. As of June 2009, articles have been published under CC-BY-NC or CC-BY licenses, unless otherwise specified.
