External validity of a population-based study on osteoporosis and fracture
DOI:
https://doi.org/10.3109/17453674.2014.920987Abstract
Background and purpose — Little is known about the characteristics of non-participants in epidemiological studies. We evaluated external validity by comparing fracture and mortality rate in participants and non-participants in a longitudinal study on risk factors for fracture.Methods — 1,604 randomly selected women, 75 years of age, were invited to attend a study on osteoporosis and fracture. 1,044 women attended the study (participants) and 560 women did not participate (non-participants). Fracture data for all were obtained prospectively from radiographic records. Mortality data were obtained through the population register. Mean follow-up was 13 (11–15) years. Cumulative survival was compared with the log-rank test. Fracture incidence rates per 1,000 person-years were compared with Mann-Whitney U-tests. In addition, fracture comparisons were made with the cumulative incidence function and Gray’s test.Results — 454 participants (44%) died during the follow-up, as compared to 372 of the non-participants (66%) (p Interpretation — Our findings suggest that participants had a lower mortality rate than non-participants. Distal forearm and vertebral fractures were more frequent in participants. However, the external validity for fractures in general appeared to be satisfactory.Downloads
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Published
2014-08-01
How to Cite
Wihlborg, A., Åkesson, K., & Gerdhem, P. (2014). External validity of a population-based study on osteoporosis and fracture. Acta Orthopaedica, 85(4), 433–437. https://doi.org/10.3109/17453674.2014.920987
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Acta Orthopaedica (Scandinavica) content is available freely online as from volume 1, 1930. The journal owner owns the copyright for all material published until volume 80, 2009. As of June 2009, the journal has however been published fully Open Access, meaning the authors retain copyright to their work. As of June 2009, articles have been published under CC-BY-NC or CC-BY licenses, unless otherwise specified.