Rabbit model of septic arthritis
DOI:
https://doi.org/10.3109/17453678709146335Abstract
Eighty-five rabbits were injected in one knee with Staphlycoccus aureus in order to study the time-related changes in untreated septic arthritis up to 3 months. In the synovial membrane a severe release of lysosomal enzymes was observed. The activity was mainly located in and around lining cells and leucocytes in the pannus demonstrating increasing destructive characteristics. This resulted in marginal erosion and undermining of the cartilage border visible from Day 5 continuing gradually to total joint destruction after 5 weeks. The glycosaminoglycan depletion was observed at the surface of the cartilage at Day 2 and was total after 2 weeks. Our infection model should permit comparison of different therapeutic measures.Downloads
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Published
1987-01-01
How to Cite
Riegels-nielsen, P., Frimodt-Möller, N., & Jensen, J. S. (1987). Rabbit model of septic arthritis. Acta Orthopaedica, 58(1), 14–19. https://doi.org/10.3109/17453678709146335
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Acta Orthopaedica (Scandinavica) content is available freely online as from volume 1, 1930. The journal owner owns the copyright for all material published until volume 80, 2009. As of June 2009, the journal has however been published fully Open Access, meaning the authors retain copyright to their work. As of June 2009, articles have been published under CC-BY-NC or CC-BY licenses, unless otherwise specified.
