Local application of growth-factor IGF-1 to healing bone Experiments with a titanium chamber in rabbits
DOI:
https://doi.org/10.3109/17453678909150132Abstract
In order to study the effects of bone healing, insulin-like growth factor 1 (IGF-1) was continuously applied with a minipump to a healing bone callus located inside a titanium chamber in a rabbit tibia. After 2 weeks, 99mTc-MDP uptake and calcium content were measured. IGF-1 decreased 99mTc-MDP uptake, and thus the mineral turnover rate, but the amount of bone mineral was unchanged. Probably the normal endogenous production of IGF-1 is already optimal for healing in this model.Downloads
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Published
1989-01-01
How to Cite
Aspenberg, P., Albrektsson, T., & Thorngren, K.-G. (1989). Local application of growth-factor IGF-1 to healing bone Experiments with a titanium chamber in rabbits. Acta Orthopaedica, 60(5), 607–610. https://doi.org/10.3109/17453678909150132
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Acta Orthopaedica (Scandinavica) content is available freely online as from volume 1, 1930. The journal owner owns the copyright for all material published until volume 80, 2009. As of June 2009, the journal has however been published fully Open Access, meaning the authors retain copyright to their work. As of June 2009, articles have been published under CC-BY-NC or CC-BY licenses, unless otherwise specified.
