Decreased levels of IGF binding protein-3 in serum from children with Perthes’ disease
DOI:
https://doi.org/10.3109/17453679809117611Abstract
The concentrations of insulin-like growth factor (IGF)-I and IGF-binding protein (IGFBP)-3 in serum obtained from 27 children with Perthes’ disease and 10 age-matched control subjects were measured by radioimmunoassay (RIA). IGFBPs were also analyzed by a Western ligand blotting (WLB) method. The bone age was determined in 18 patients from hand-wrist radiographs. Serum levels of IGFBP-3 but not IGF-I were significantly lower than those in normal controls. WLB showed a decrease in the intensity of the IGFBP-3 band in 19 of the 27 patients. The bone age was delayed, 2 years or more compared with the chronological age in 7 of 18 patients, and all of them, except 1, showed decreased levels of IGFBP-3 on WLB. We conclude that there may be disturbances in availability of IGFs in some patients with Perthes’ disease.Downloads
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Published
1998-01-01
How to Cite
Matsumoto, T., Enomoto, H., Takahashi, K., & Motokawa, S. (1998). Decreased levels of IGF binding protein-3 in serum from children with Perthes’ disease. Acta Orthopaedica, 69(2), 125–128. https://doi.org/10.3109/17453679809117611
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Acta Orthopaedica (Scandinavica) content is available freely online as from volume 1, 1930. The journal owner owns the copyright for all material published until volume 80, 2009. As of June 2009, the journal has however been published fully Open Access, meaning the authors retain copyright to their work. As of June 2009, articles have been published under CC-BY-NC or CC-BY licenses, unless otherwise specified.
