The effect of flurbiprofen and tiaprofenic acid on serum cytokine levels of patients with osteoarthrosis

Authors

  • Hafize Uzun
  • Sansin Tuzun
  • Nihal Ozaras
  • Seval Aydin
  • Resat Ozaras
  • Safiye Dondurmaci
  • Fikret Tuzun

DOI:

https://doi.org/10.1080/000164701753532844

Abstract

39 patients with active knee osteoarthrosis, chosen according to ACR criteria, were assigned to receive flurbiprofen (n 12, 2 2 100 mg), tiaprofenic acid (n 14, 2 2 300 mg) and placebo (n 13) in a 3-week, placebo-controlled study. All patients completed the study, and both medications were found to be effective: improvement occurred in the clinical signs. These drugs reduced the TNF- f levels. Flurbiprofen especially affected the IL-6 levels. Our findings indicate that NSAIDs may be effective in the etiopathogenesis of osteoarthrosis.

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Published

2001-01-01

How to Cite

Uzun, H., Tuzun, S., Ozaras, N., Aydin, S., Ozaras, R., Dondurmaci, S., & Tuzun, F. (2001). The effect of flurbiprofen and tiaprofenic acid on serum cytokine levels of patients with osteoarthrosis. Acta Orthopaedica, 72(5), 499–502. https://doi.org/10.1080/000164701753532844