Demographics and risk for containment surgery in patients with unilateral Legg–Calvé–Perthes disease: a national population-based cohort study of 309 patients from the Swedish Pediatric Orthopedic Quality Register

Authors

DOI:

https://doi.org/10.2340/17453674.2024.40907

Keywords:

Demographics, Hip, Incidence, LCPD, Paediatric orthopaedics, Pelvis and acetabulum, SPOQ

Abstract

Background and purpose: It is controversial as to which patients affected by Legg–Calvé–Perthes disease (LCPD) benefit from containment surgery. This population-based study based on data from a national quality registry aims to assess the incidence of LCPD and to explore which factors affect the decision for surgical intervention.
Methods: This observational study involved 309 patients with unilateral LCPD reported between 2015 and 2023 to the Swedish Pediatric Orthopedic Quality Register (SPOQ). Descriptive statistics and logistic regression models were used for analysis.
Results: In 2019, the assessed incidence of LCPD in the Swedish population of 2–12-year-olds was 4.2 per 105. 238 (77%) were boys with a mean age of 6 years. At diagnosis, 55 (30%) were overweight or obese, rising to 17 patients (39%) and 16 patients (40%) at 2-year follow-up for surgically and non-surgically treated groups, respectively. At diagnosis, affected hips had reduced abduction compared with healthy hips, and their abduction remained restricted at the 2-year follow-up. Surgically treated patients had inferior abduction compared with non-surgically treated ones at diagnosis. The adjusted risk for containment surgery increased with age and in the presence of a positive Trendelenburg sign but decreased with greater hip abduction.
Conclusion: We found a lower national yearly incidence (4.2 per 105) than previously reported in Swedish studies. A higher proportion of overweight or obese patients compared with the general Swedish population of 4–9-year-olds was identified. Increasing age, positive Trendelenburg sign, and limited hip abduction at diagnosis correlated with increased surgical intervention likelihood.

Downloads

Download data is not yet available.

References

Tannast M, Macintyre N, Steppacher S D, Hosalkar H S, Ganz R, Siebenrock K A. A systematic approach to analyse the sequelae of LCPD. Hip Int 2013; 23(Suppl 9): S61-70. doi: 10.5301/hipint.5000071. DOI: https://doi.org/10.5301/hipint.5000071

Ng T, Liu R, Kulkarni V A. Legg–Calvé–Perthes disease: diagnosis, decision making, and outcome. Curr Sports Med Rep 2024; 23(2): 45-52. doi: 10.1249/JSR.0000000000001139. DOI: https://doi.org/10.1249/JSR.0000000000001139

Loder R T, Skopelja E N. The epidemiology and demographics of Legg-Calvé-Perthes’ disease. ISRN Orthop 2011; 2011: 504393. doi: 10.5402/2011/504393. DOI: https://doi.org/10.5402/2011/504393

Moberg A, Rehnberg L. Incidence of Perthes’ disease in Uppsala, Sweden. Acta Orthop Scand 1992; 63(2): 157-8. doi: 10.3109/17453679209154813. DOI: https://doi.org/10.3109/17453679209154813

Johansson T, Lindblad M, Bladh M, Josefsson A, Sydsjö G. Incidence of Perthes’ disease in children born between 1973 and 1993. Acta Orthop 2017; 88(1): 96-100. doi: 10.1080/17453674.2016.1227055. DOI: https://doi.org/10.1080/17453674.2016.1227055

von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP; STROBE Initiative. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. BMJ. 2007 Oct 20;335(7624):806-8. doi: 10.1136/bmj.39335.541782.AD. DOI: https://doi.org/10.1136/bmj.39335.541782.AD

Georgiadis A G, Seeley M A, Yellin J L, Sankar W N. The presentation of Legg–Calvé–Perthes disease in females. J Child Orthop 2015; 9(4): 243-7. doi: 10.1007/s11832-015-0671-y. DOI: https://doi.org/10.1007/s11832-015-0671-y

Guille J T, Lipton G E, Szöke G, Bowen J R, Harcke H T, Glutting J J. Legg–Calvé–Perthes disease in girls: a comparison of the results with those seen in boys. J Bone Joint Surg Am 1998; 80(9): 1256-63. doi: 10.2106/00004623-199809000-00002. DOI: https://doi.org/10.2106/00004623-199809000-00002

Wynne-Davies R. Some etiologic factors in Perthes’ disease. Clin Orthop Relat Res 1980; (150): 12-5. PMID: 7428209.

Neal D C, Alford T H, Moualeu A, Jo C H, Herring J A, Kim H K. Prevalence of obesity in patients with Legg–Calvé–Perthes disease. J Am Acad Orthop Surg 2016; 24(9): 660-5. doi: 10.5435/JAAOS-D-16-00120. DOI: https://doi.org/10.5435/JAAOS-D-16-00120

Hailer Y D, Hailer N P. Is Legg–Calvé–Perthes disease a local manifestation of a systemic condition? Clin Orthop Relat Res 2018; 476(5): 1055-64. doi: 10.1007/s11999.0000000000000214. DOI: https://doi.org/10.1007/s11999.0000000000000214

Laine J C, Novotny S A, Tis J E, Sankar W N, Martin B D, Kelly D M, et al.; International Perthes Study Group. Demographics and clinical presentation of early-stage Legg–Calvé–Perthes disease: a prospective, multicenter, international Study. J Am Acad Orthop Surg 2021; 29(2): e85-e91. doi: 10.5435/JAAOS-D-19-00379. DOI: https://doi.org/10.5435/JAAOS-D-19-00379

Mörlin G B, Hailer Y D. High blood pressure and overweight in children with Legg–Calvé–Perthes disease: a nationwide population-based cohort study. BMC Musculoskelet Disord 2021; 22(1): 32. doi: 10.1186/s12891-020-03889-9. DOI: https://doi.org/10.1186/s12891-020-03889-9

Hög förekomst av övervikt och fetma bland skolelever [Internet] 2023 [cited 2024 Mar 20]. Available from: https://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2023/juni/hog-forekomst-av-overvikt-och-fetma-bland-skolelever/

Statistik om övervikt och fetma hos barn 0-5 år [Internet] 2020 [cited 2024 Mar 20]. Available from: https://www.folkhalsomyndigheten.se/livsvillkor-levnadsvanor/mat-fysisk-aktivitet-overvikt-och-fetma/overvikt-och-fetma/statistik-om-overvikt-och-fetma/overvikt-och-fetma-hos-barn-0-5-ar/

Novotny S A, Hailer Y D, Laine J C, Wetzel M, Gillespie S E, Gilbert S R, et al.; International Perthes Study Group. Do weightbearing restrictions cause excess weight gain in children with Legg–Calvé–Perthes Disease? J Pediatr Orthop 2023; 43(1): 31-6. doi: 10.1097/BPO.0000000000002264. DOI: https://doi.org/10.1097/BPO.0000000000002264

Moraeus L, Lissner L, Olsson L, Sjöberg A. Age and time effects on children’s lifestyle and overweight in Sweden. BMC Public Health 2015; 15:355. doi: 10.1186/s12889-015-1635-3. DOI: https://doi.org/10.1186/s12889-015-1635-3

NCD Risk Factor Collaboration (NCD-RisC).Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128.9 million children, adolescents, and adults. Lancet 2017; 390(10113): 2627-42. doi: 10.1016/S0140-6736(17)32129-3. DOI: https://doi.org/10.1016/S0140-6736(17)32129-3

Rampal V, Clément J L, Solla F. Legg–Calvé–Perthes disease: classifications and prognostic factors. Clin Cases Miner Bone Metab 2017; 14(1): 74-82. doi: 10.11138/ccmbm/2017.14.1.074. DOI: https://doi.org/10.11138/ccmbm/2017.14.1.074

Kollitz K M, Gee A O. Classifications in brief: the Herring lateral pillar classification for Legg–Calvé–Perthes disease. Clin Orthop Relat Res 2013; 471(7): 2068-72. doi: 10.1007/s11999-013-2992-9. DOI: https://doi.org/10.1007/s11999-013-2992-9

Hyman J E, Trupia E P, Wright M L, Matsumoto H, Jo C H, Mulpuri K, et al.; International Perthes Study Group Members. Interobserver and intraobserver reliability of the modified Waldenström classification system for staging of Legg–Calvé–Perthes disease. J Bone Joint Surg Am 2015; 97(8): 643-50. doi: 10.2106/JBJS.N.00887. DOI: https://doi.org/10.2106/JBJS.N.00887

Hailer Y D, Penno E. Agreement of radiographic measurements and patient-reported outcome in 61 patients with Legg–Calvé–Perthes disease at mean follow-up of 28 years. J Pediatr Orthop B 2019; 28(2): 100-6. doi: 10.1097/BPB.0000000000000563. DOI: https://doi.org/10.1097/BPB.0000000000000563

Melin L, Rendek Z, Hailer Y D. Recommendations for physiotherapy and physical activity for children with Legg–Calvé–Perthes disease: a survey of pediatric orthopedic surgeons and physiotherapists in Sweden. Acta Orthop 2023; 94: 432-7. doi: 10.2340/17453674.2023.18341. DOI: https://doi.org/10.2340/17453674.2023.18341

Canavese F, Dimeglio A. Perthes’ disease: prognosis in children under six years of age. J Bone Joint Surg Br 2008; 90(7): 940-5. doi: 10.1302/0301-620X.90B7.20691. DOI: https://doi.org/10.1302/0301-620X.90B7.20691

Joseph B. Natural history of early onset and late-onset Legg–Calve–Perthes disease. J Pediatr Orthop 2011; 31(2 Suppl): S152-5. doi: 10.1097/BPO.0b013e318223b423. DOI: https://doi.org/10.1097/BPO.0b013e318223b423

Wiig O, Terjesen T, Svenningsen S. Prognostic factors and outcome of treatment in Perthes’ disease: a prospective study of 368 patients with five-year follow-up. J Bone Joint Surg Br 2008; 90(10): 1364-71. doi: 10.1302/0301-620X.90B10.20649. DOI: https://doi.org/10.1302/0301-620X.90B10.20649

Herring J A, Kim H T, Browne R. Legg–Calve–Perthes disease. Part II: Prospective multicenter study of the effect of treatment on outcome. J Bone Joint Surg Am 2004; 86(10): 2121-34. PMID: 15466720.

Kim H K. Legg–Calvé–Perthes disease. J Am Acad Orthop Surg 2010; 18(11): 676-86. doi: 10.5435/00124635-201011000-00005. DOI: https://doi.org/10.5435/00124635-201011000-00005

Froberg L, Christensen F, Pedersen N W, Overgaard S. The need for total hip arthroplasty in Perthes disease: a long-term study. Clin Orthop Relat Res 2011; 469(4): 1134-40. doi: 10.1007/s11999-010-1566-3. DOI: https://doi.org/10.1007/s11999-010-1566-3

Engesæter L B, Engesæter I Ø, Fenstad A M, Havelin L I, Kärrholm J, Garellick G, et al. Low revision rate after total hip arthroplasty in patients with pediatric hip diseases. Acta Orthop 2012; 83(5): 436-41. doi: 10.3109/17453674.2012.736171. DOI: https://doi.org/10.3109/17453674.2012.736171

Leroux J, Abu Amara S, Lechevallier J. Legg–Calvé–Perthes disease. Orthop Traumatol Surg Res 2018; 104(1S): S107-S112. doi: 10.1016/j.otsr.2017.04.012. DOI: https://doi.org/10.1016/j.otsr.2017.04.012

Perry D C, Arch B, Appelbe D, Francis P, Craven J, Monsell FP, et al.; BOSS collaborators. The British Orthopaedic Surgery Surveillance study: Perthes’ disease: the epidemiology and two-year outcomes from a prospective cohort in Great Britain. Bone Joint J 2022; 104-B(4): 510-18. doi: 10.1302/0301-620X.104B4.BJJ-2021-1708.R1. DOI: https://doi.org/10.1302/0301-620X.104B4.BJJ-2021-1708.R1

Sankar W N, Laird C T, Baldwin K D. Hip range of motion in children: what is the norm? J Pediatr Orthop 2012; 32(4): 399-405. doi: 10.1097/BPO.0b013e3182519683. DOI: https://doi.org/10.1097/BPO.0b013e3182519683

Herngren B. Svenskt Barnortopediskt Qvalitetsregister SPOQ. Available from: http://www.spoq.se. :101.

Published

2024-06-18

How to Cite

Wadström, M. G., Hailer, N. P., & Hailer, Y. D. (2024). Demographics and risk for containment surgery in patients with unilateral Legg–Calvé–Perthes disease: a national population-based cohort study of 309 patients from the Swedish Pediatric Orthopedic Quality Register. Acta Orthopaedica, 95, 333–339. https://doi.org/10.2340/17453674.2024.40907