The use of antibiotic-loaded bone cement and systemic antibiotic prophylactic use in 2,971,357 primary total knee arthroplasties from 2010 to 2020: an international register-based observational study among countries in Africa, Europe, North America, and Oceania

Authors

  • Tesfaye H Leta The Norwegian Arthroplasty Register, Department of Orthopedic Surgery, Haukeland University Hospital, Norway; Faculty of Health Science, VID Specialized University, Norway; Department of Population Health Sciences, Weill Medical College of Cornell University, USA; Department of Medical Device Surveillance & Assessment, Kaiser Permanente, USA
  • Anne Marie Fenstad The Norwegian Arthroplasty Register, Department of Orthopedic Surgery, Haukeland University Hospital, Norway https://orcid.org/0000-0002-6429-0153
  • Stein Håkon L Lygre The Norwegian Arthroplasty Register, Department of Orthopedic Surgery, Haukeland University Hospital, Norway; Department of Occupational Medicine, Haukeland University Hospital, Norway
  • Stein Atle Lie The Norwegian Arthroplasty Register, Department of Orthopedic Surgery, Haukeland University Hospital, Norway; Institutes of Dentistry, University of Bergen, Norway
  • Martin Lindberg-Larsen The Danish Knee Arthroplasty Register, Denmark; Department of Orthopedic Surgery and Traumatology, Odense University Hospital, Denmark https://orcid.org/0000-0002-4483-677X
  • Alma B Pedersen The Danish Knee Arthroplasty Register, Denmark; Department of Clinical Epidemiology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University, Denmark https://orcid.org/0000-0002-3288-9401
  • Annette W-Dahl The Swedish Arthroplasty Register, Sweden; Department of Clinical Sciences Lund, Division of Orthopedics, Lund University, Lund, Sweden https://orcid.org/0000-0003-4053-7358
  • Ola Rolfson The Swedish Arthroplasty Register, Sweden; Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden https://orcid.org/0000-0001-6534-1242
  • Erik Bülow Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Centre of Registers Västra Götaland, Gothenburg, Sweden https://orcid.org/0000-0002-9973-456X
  • James A Ashforth JointCare Registry, South Africa
  • Liza N van Steenbergen The Dutch Arthroplasty Register, the Netherlands https://orcid.org/0000-0002-8141-842X
  • Rob G H H Nelissen The Dutch Arthroplasty Register, the Netherlands; Department of Orthopedics, Leiden University Medical Center, the Netherlands https://orcid.org/0000-0003-1228-4162
  • Dylan Harries South Australian Health and Medical Research Institute, Australia
  • Richard De Steiger The Australian Orthopaedic Association National Joint Replacement Registry, Australia https://orcid.org/0000-0002-1276-2040
  • Olav Lutro Department of Medicine, Stavanger University Hospital, Norway https://orcid.org/0000-0003-3312-3712
  • Emmi Hakulinen The Finnish Institute for Health and Welfare, Finland
  • Keijo Mäkelä The Finnish Arthroplasty Register, Finland; Turku University Hospital and University of Turku, Turku, Finland
  • Jinny Willis The New Zealand Joint Registry, New Zealand
  • Michael Wyatt The New Zealand Joint Registry, New Zealand https://orcid.org/0000-0001-5283-2608
  • Chris Frampton The New Zealand Joint Registry, New Zealand
  • Alexander Grimberg The Germany Arthroplasty Registry, Germany https://orcid.org/0000-0001-8062-788X
  • Arnd Steinbrück The Germany Arthroplasty Registry, Germany
  • Yinan Wu The Germany Arthroplasty Registry, Germany
  • Cristiana Armaroli Arthroplasty Registry of the Autonomous Province of Trento (PATN), Clinical Epidemiology Service, Provincial Agency for Health Services of Trento (APSS), Italy
  • Marco Molinari Orthopedics and Traumatology Operative Unit, Cavalese Hospital, Provincial Agency for Health Services of Trento (APSS), Italy
  • Roberto Picus Arthroplasty Register of Autonomous Province of Bolzano (PABZ), Observatory of Health, Health Department AP of Bolzano, Italy
  • Kyle Mullen American Joint Replacement Registry, USA
  • Richard Illgen American Joint Replacement Registry, USA; University of Wisconsin-Madison School of Medicine and Public Health, Department of Orthopedic Surgery and Rehabilitation, USA
  • Ioan C Stoica Romanian Arthroplasty Registry, Romania; University of Medicine and Pharmacy – Carol Davila – Bucharest – UMFCD Bucharest, Romania; Foisor Orthopedic Hospital, Romania
  • Andreea E Vorovenci Romanian Arthroplasty Registry, Romania; Economic Cybernetics and Statistics Doctoral School, Bucharest University of Economic Studies, Romania
  • Dan Dragomirescu Romanian Arthroplasty Registry, Romania; Economic Cybernetics and Statistics Doctoral School, Bucharest University of Economic Studies, Romania
  • Håvard Dale The Norwegian Arthroplasty Register, Department of Orthopedic Surgery, Haukeland University Hospital, Norway; Department of Clinical Medicine, Faculty of Medicine, University of Bergen, Norway
  • Christian Brand Swiss National Hip & Knee Joint Registry, Switzerland; Institute of Social and Preventive Medicine, SwissRDL, University of Bern; Switzerland
  • Bernhard Christen Swiss National Hip & Knee Joint Registry, Switzerland; Articon, Bern, Switzerland
  • Joanne Shapiro The National Joint Registry for England, Wales, Northern Ireland, The Isle of Man and Guernsey, UK; NEC Software Solutions, Hemel Hempstead, UK
  • J Mark Wilkinson The National Joint Registry for England, Wales, Northern Ireland, The Isle of Man and Guernsey, UK; Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK
  • Richard Armstrong The National Joint Registry for England, Wales, Northern Ireland, The Isle of Man and Guernsey, UK; NEC Software Solutions, Hemel Hempstead, UK
  • Kate Wooster The National Joint Registry for England, Wales, Northern Ireland, The Isle of Man and Guernsey, UK; NEC Software Solutions, Hemel Hempstead, UK
  • Geir Hallan The Norwegian Arthroplasty Register, Department of Orthopedic Surgery, Haukeland University Hospital, Norway; Department of Clinical Medicine, Faculty of Medicine, University of Bergen, Norway
  • Jan-Erik Gjertsen The Norwegian Arthroplasty Register, Department of Orthopedic Surgery, Haukeland University Hospital, Norway; Department of Clinical Medicine, Faculty of Medicine, University of Bergen, Norway https://orcid.org/0000-0002-8490-268X
  • Richard N Chang Medical Device Surveillance & Assessment, Kaiser Permanente, USA
  • Heather A Prentice Medical Device Surveillance & Assessment, Kaiser Permanente, USA https://orcid.org/0000-0002-2200-6564
  • Elizabeth W Paxton Medical Device Surveillance & Assessment, Kaiser Permanente, USA
  • Ove Furnes The Norwegian Arthroplasty Register, Department of Orthopedic Surgery, Haukeland University Hospital, Norway; Department of Clinical Medicine, Faculty of Medicine, University of Bergen, Norway https://orcid.org/0000-0001-8223-2515

DOI:

https://doi.org/10.2340/17453674.2023.17737

Keywords:

Antibitic-loaded bone cement, Arthroplasty, Implants, Joint arthroplasty registry, Knee, Systemic antbiotic prophylactic

Abstract

Background and purpose: Antibiotic-loaded bone cement (ALBC) and systemic antibiotic prophylaxis (SAP) have been used to reduce periprosthetic joint infection (PJI) rates. We investigated the use of ALBC and SAP in primary total knee arthroplasty (TKA).
Patients and methods: This observational study is based on 2,971,357 primary TKAs reported in 2010–2020 to national/regional joint arthroplasty registries in Australia, Denmark, Finland, Germany, Italy, the Netherlands, New Zealand, Norway, Romania, South Africa, Sweden, Switzerland, the UK, and the USA. Aggregate-level data on trends and types of bone cement, antibiotic agents, and doses and duration of SAP used was extracted from participating registries.
Results: ALBC was used in 77% of the TKAs with variation ranging from 100% in Norway to 31% in the USA. Palacos R+G was the most common (62%) ALBC type used. The primary antibiotic used in ALBC was gentamicin (94%). Use of ALBC in combination with SAP was common practice (77%). Cefazolin was the most common (32%) SAP agent. The doses and duration of SAP used varied from one single preoperative dosage as standard practice in Bolzano, Italy (98%) to 1-day 4 doses in Norway (83% of the 40,709 TKAs reported to the Norwegian arthroplasty register).
Conclusion: The proportion of ALBC usage in primary TKA varies internationally, with gentamicin being the most common antibiotic. ALBC in combination with SAP was common practice, with cefazolin the most common SAP agent. The type of ALBC and type, dose, and duration of SAP varied among participating countries.

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2023-08-09

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Leta, T. H., Fenstad, A. M., Lygre, S. H. L., Lie, S. A., Lindberg-Larsen, M., Pedersen, A. B., W-Dahl, A., Rolfson, O., Bülow, E., Ashforth, J. A., van Steenbergen, L. N., Nelissen, R. G. H. H., Harries, D., De Steiger, R., Lutro, O., Hakulinen, E., Mäkelä, K., Willis, J., Wyatt, M., Frampton, C., Grimberg, A., Steinbrück, A., Wu, Y., Armaroli, C., Molinari, M., Picus, R., Mullen, K., Illgen, R., Stoica, I. C., Vorovenci, A. E., Dragomirescu, D., Dale, H., Brand, C., Christen, B., Shapiro, J., Wilkinson, J. M., Armstrong, R., Wooster, K., Hallan, G., Gjertsen, J.-E., Chang, R. N., Prentice, H. A., Paxton, E. W., & Furnes, O. (2023). The use of antibiotic-loaded bone cement and systemic antibiotic prophylactic use in 2,971,357 primary total knee arthroplasties from 2010 to 2020: an international register-based observational study among countries in Africa, Europe, North America, and Oceania. Acta Orthopaedica, 94, 416–425. https://doi.org/10.2340/17453674.2023.17737

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Vol. 94 (2023): Acta Orthopaedica

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Copyright (c) 2023 Tesfaye H Leta, Anne Marie Fenstad, Stein Håkon L Lygre, Stein Atle Lie, Martin Lindberg-Larsen, Alma B Pedersen, Annette W-Dahl, Ola Rolfson, Erik Bülow, James A Ashforth, Liza N van Steenbergen, Rob G H H Nelissen, Dylan Harries, Richard De Steiger, Olav Lutro, Emmi Hakulinen, Keijo Mäkelä, Jinny Willis, Michael Wyatt, Chris Frampton, Alexander Grimberg, Arnd Steinbrück, Yinan Wu, Cristiana Armaroli, Marco Molinari, Roberto Picus, Kyle Mullen, Richard Illgen, Ioan C Stoica, Andreea E Vorovenci, Dan Dragomirescu, Håvard Dale, Christian Brand, Bernhard Christen, Joanne Shapiro, J Mark Wilkinson, Richard Armstrong, Kate Wooster, Geir Hallan, Jan-Erik Gjertsen, Richard N Chang, Heather A Prentice, Elizabeth W Paxton, Ove Furnes

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Acta Orthopaedica (Scandinavica) content is available freely online as from volume 1, 1930. The journal owner owns the copyright for all material published until volume 80, 2009. As of June 2009, the journal has however been published fully Open Access, meaning the authors retain copyright to their work. As of June 2009, articles have been published under CC-BY-NC or CC-BY licenses, unless otherwise specified.
 
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