Computed tomography-based radiostereometric analysis in orthopedic research: practical guidelines


  • Olof H Sandberg Sectra AB, Linköping, Sweden
  • Johan Kärrholm University of Göteborg, Göteborg, Sweden
  • Henrik Olivecrona Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden
  • Stephan M Röhrl Division of Orthopaedic Surgery, Oslo University Hospital, Oslo, Norway
  • Olof G Sköldenberg Department of Clinical Sciences, Unit of Orthopaedics, Karolinska Institutet, Stockholm, Sweden
  • Cyrus Brodén Department of Surgical Sciences, Orthopaedics, Uppsala University Hospital, Sweden



Arthroplasty, CT-based radiostereometric analysis, Implants, radiostereometric analysis


Early implant migration is an indicator of the long-term survival/failure of implants. CT-based radio-stereometric analysis (CT-RSA) is a precise method for measuring and visualizing implant migration in vivo using image processing of CT scans. This makes the method widely applicable to orthopedic researcher.
Since its development in the early 2000s, CT-RSA has benefited from breakthroughs in CT and computing technology. These advancements have allowed for the acquisition of images with higher resolution at a much lower radiation dose. As a result, the measurement precision of CT-RSA is now comparable to that of the current gold standard technology while still compatible with most ethical considerations regarding radiation exposure.
In this review we present bests practices for the successful execution of CT-RSA research projects. These practices are based on experience from projects on the hip, knee, shoulder, lower back, cervical spine, foot, pelvis, and wrist.



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How to Cite

Sandberg, O. H., Kärrholm, J., Olivecrona, H., Röhrl, S. M., Sköldenberg, O. G., & Brodén, C. (2023). Computed tomography-based radiostereometric analysis in orthopedic research: practical guidelines. Acta Orthopaedica, 94, 373–378.

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