Skin Treatment with Bepanthen Cream Versus No Cream During Radiotherapy: A randomized controlled trial

Authors

  • Erik Løkkevik Department of Oncology, The Norwegian Radium Hospital (E. Løkkevik, E. Skovlund, J. B. Reitan, E. Hannisdal, G. Tanum), Oslo, Norway; Section of Medical Statistics, University of Oslo (E. Skovlund), Oslo, Norway; Radiation Medicine Department, Norwegian Radiation Protection Authority (J. B. Reitan), Oslo, Norway
  • Eva Skovlund Department of Oncology, The Norwegian Radium Hospital (E. Løkkevik, E. Skovlund, J. B. Reitan, E. Hannisdal, G. Tanum), Oslo, Norway; Section of Medical Statistics, University of Oslo (E. Skovlund), Oslo, Norway; Radiation Medicine Department, Norwegian Radiation Protection Authority (J. B. Reitan), Oslo, Norway
  • Jon B. Reitan Department of Oncology, The Norwegian Radium Hospital (E. Løkkevik, E. Skovlund, J. B. Reitan, E. Hannisdal, G. Tanum), Oslo, Norway; Section of Medical Statistics, University of Oslo (E. Skovlund), Oslo, Norway; Radiation Medicine Department, Norwegian Radiation Protection Authority (J. B. Reitan), Oslo, Norway
  • Einar Hannisdal Department of Oncology, The Norwegian Radium Hospital (E. Løkkevik, E. Skovlund, J. B. Reitan, E. Hannisdal, G. Tanum), Oslo, Norway; Section of Medical Statistics, University of Oslo (E. Skovlund), Oslo, Norway; Radiation Medicine Department, Norwegian Radiation Protection Authority (J. B. Reitan), Oslo, Norway
  • Gunnar Tanum Department of Oncology, The Norwegian Radium Hospital (E. Løkkevik, E. Skovlund, J. B. Reitan, E. Hannisdal, G. Tanum), Oslo, Norway; Section of Medical Statistics, University of Oslo (E. Skovlund), Oslo, Norway; Radiation Medicine Department, Norwegian Radiation Protection Authority (J. B. Reitan), Oslo, Norway

DOI:

https://doi.org/10.3109/02841869609100721

Abstract

In several radiotherapy departments, dexpanthenol cream (Bepanthen ‘Roche’) has been used extensively to ameliorate acute radiotherapy skin reactions. The evidence base for this practice is obscure as no randomized trials have been performed. In the present clinical prospective study of 86 patients we have compared Bepanthen cream with no topical ointment at all. The cream was applied on randomly selected parts of treatment fields in laryngeal and breast cancer patients, and so each patient acted as his own control. Seven patients were withdrawn from analysis. Scoring of skin reactions in 16 laryngeal and 63 breast cancer patients was performed without knowledge of which area that had been given cream or not. Endpoints were a modified skin reaction grading according to EORTC/RTOG, and itching/pain in treated fields. The study did not indicate any clinically important benefits of using Bepanthen cream for ameliorating radiogenic skin reactions under the conditions applied.

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Published

1996-01-01

How to Cite

Løkkevik, E., Skovlund, E., Reitan, J. B., Hannisdal, E., & Tanum, G. (1996). Skin Treatment with Bepanthen Cream Versus No Cream During Radiotherapy: A randomized controlled trial. Acta Oncologica, 35(8), 1021–1026. https://doi.org/10.3109/02841869609100721

Issue

Vol. 35 No. 8 (1996): Acta Oncologica

Section

Articles