Manuscript layout

Title The title should include information on the results of the investigation, including the number of patients, average follow-up, and animal or cadaver experiments. Acta prefers titles that are expressive rather than neutral. The first name, middle initial(s), and last name of each author should be given with department affiliations as well as the e-mail of the corresponding author.

Abstract The abstract should not exceed 250 words. It should consist of 4 parts: Background and purpose (motive for the study, i.e. why was it done), Patients/material/animals and methods, Results, and Interpretation.

Introduction The introduction should focus on the state of knowledge at the beginning of the study. The aims and main hypothesis of the study should be stated clearly. Only in exceptional cases should it exceed 300 words.

Patients/material/animals and methods The selection of subjects and the inclusion or exclusion criteria should be described. Subjects who declined to participate, withdrawals and those with incomplete follow-up should be accounted for. Describe in detail how the measurements were made and the techniques used.

Statistics See separate heading.

Ethics, registration, data sharing plan, funding, and potential conflicts of interest Approval by the local Ethics committee should be stated with date of issue and registration number. Registration applies to registration of clinical trials in for example Give registration number. Data sharing plan applies to clinical trials that began enrolling participants on or after 1 January 2019 which must include a data sharing plan in the trial's registration. Acta encourages data sharing of also other studies. Funding and potential conflicts of interest should be declared.

Results Do not give the same data in more than 1 way. When summarizing the data, always include measures of variability and the number of subjects. Give the median and range—e.g., 60 years (35–70), the mean and standard deviation—59 years (SD 15), and the frequencies for nominal data. The results of matched data should be given in relevant form (e.g., the distribution of pairwise differences).
Percentages should not be used if the sample size is less than 100. Give numbers in digits in stead of words, even if n<10 or at start of sentence (4 in stead of four, and 4th instead of fourth).
Present confidence intervals as 2.2(CI 0.6-2.4), define 95% confidence interval as CI under "Statistics". Give p-values with only 1 numeral (except 0), e.g. “p-value=0.893” should be “p-value 0.9”. P-values are unnecessary when confidence intervals are used.
Refrain from meaningless decimals, e.g. rewrite “RR 5.86 (CI 2.03 – 18.38)” to “RR 6 (CI 2-18)”.

Discussion This section should contain a critical discussion of the results—e.g., the quality of the data (selection and information bias) and adequacy of the statistical analysis (confounding bias). It should also assess the relevant literature for or against the findings and if possible, the conclusions as regards clinical application or further research. Discuss, do not recapitulate, your results.

Tables Each table should be self-explanatory, with an adequate title and a logical presentation of the data. Abbreviate words in the columns and explain in footnotes. Each column heading for numerical data should include the unit of measurement. Use SI units. Avoid unnecessary decimals! It is seldom advisable to use more than 2 digits for biologic measurements.

Figures A scanned picture or digital photo should usually be about 85 mm (i.e. 1000 pixels) wide with a resolution of 300 DPI (dots per inch), which gives a square picture an uncompressed file size of 4.5 MiB in color and 1 MiB in gray-scale. A black and white drawing or graph may be scanned in 800 DPI bitmap, i.e. 1 bit TIFF. The preferred format is a TIFF-file. The resolution of WEB illustrations (gif) is usually too poor. Color photos should be in CMYK colors. The cost of color will be paid by Acta.
Highlights, arrows and letters may be added to digital photos but keep a clean version of the photo for the layout process. Acta prefers to add these as a separate layer.
For digital graphs, use a graphics program that can export vectorized graphs as EMF, EPS or PDF files. Avoid frames around diagrams, diagrams with perspective drawing, and bar graphs or histograms (use tables). Symbols should be consistent throughout a series of figures. Each axis should be horizontally labeled, with a description of the variable it represents. Axes should be equal in length to make the diagrams quadratic. Use sans serif letters (Arial or Helvetica). Make diagrams in color but avoid complex patterns.

Author contributions Describe in short what each author did (initials).

Acknowledgments Technical help or other help may be acknowledged.

References The number of references typically does not exceed 25 (except for meta-analyses or review articles). We prefer the references inserted in the text to be cited by name and year (chronologically) of publication in the text instead of giving their numbers, i.e. 1 author, 2 authors or author et al. and year. In the reference list no numbering of references which should be given in alphabetical order and all authors should be included. References with same author and year should be separated by adding a letter to the year (a, b, c...) in the list and the text.

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